MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity

Table 1 Summary of miRNA and early detection

miRNA and early detection		Summary
Micro RNA	Ref.
miR-135b	New article [12,23]	Tumor initiation, progression
miR-106a	[24,25]	Improves sensitivity of FOBT
miR-431	[29]	Diagnosis of colorectal adenocarcinoma
miR-15b	[29]	Diagnosis of colorectal adenocarcinoma
miR-139-3p	[29]	Diagnosis of colorectal adenocarcinoma
miR-532-3p	[29]	Diagnosis of colorectal adenocarcinoma
miR-331	[29]	Diagnosis of colorectal adenocarcinoma
miR-195	[29]	Diagnosis of colorectal adenocarcinoma
miR-17	[29]	Diagnosis of colorectal adenocarcinoma
miR-142-3p	[29]	Diagnosis of colorectal adenocarcinoma
miR-15b	[29]	Diagnosis of colorectal adenocarcinoma
miR-532	[29]	Diagnosis of colorectal adenocarcinoma
miR-652	[29]	Diagnosis of colorectal adenocarcinoma
miR193a-3p	[30]	Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-23a	[30]	Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-338-5p	[30]	Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-18a	[32]	Diagnosis of colorectal adenocarcinoma
miR-20a	[32]	Diagnosis of colorectal adenocarcinoma
miR-21	[32]	Diagnosis of colorectal adenocarcinoma
miR-29a	[32]	Diagnosis of colorectal adenocarcinoma
miR-92a	[32]	Diagnosis of colorectal adenocarcinoma
miR-106b	[32]	Diagnosis of colorectal adenocarcinoma
miR-133a	[32]	Diagnosis of colorectal adenocarcinoma
miR-143	[32]	Diagnosis of colorectal adenocarcinoma
miR-145	[32]	Diagnosis of colorectal adenocarcinoma
miR-1288	[33,34]	Control for miRNA in colorectal cancer

FOBT: Fecal occult blood testing.

Table 2 Summary of miRNA and prognosis

miRNA and prognosis		Summary
Micro RNA	Ref.
miR-200c	[35-38]	Increased expression level predicts worse prognosis
miR-378	[46]	Potential prognostic biomarker
miR-126	[47]	Potential prognostic biomarker
miR-224	[48,49]	Potential prognostic biomarker
miR-429	[50]	Potential prognostic biomarker
miR-182	[51]	Potential prognostic biomarker
mir-32	[52]	Potential prognostic biomarker
miR-214	[53]	Potential prognostic biomarker
miR-182	[54]	Potential prognostic biomarker
miR-92a	[55]	Potential prognostic biomarker
miR-124	[56]	Potential prognostic biomarker
miR-30b	[57]	Potential prognostic biomarker
miR-625	[58]	Potential prognostic biomarker
miR-155	[37]	Potential prognostic biomarker
miR-210	[37]	Potential prognostic biomarker
miR-215	[59]	Potential prognostic biomarker
miR-130b	[60]	Potential prognostic biomarker
miR-148b	[61]	Potential prognostic biomarker
miR-148	[61]	Potential prognostic biomarker
miR-16	[62]	Potential prognostic biomarker
miR-21	[10,39-45,47,65-68]	Upregulated in CRC, associated with tumor size, distant metastasis, poor survival and independent biomarker

CRC: Colorectal cancer.

Table 3 Summary of miRNA and chemosensitivity

miRNA and chemosensitivity		Summary
Micro RNA	Ref.
miR-21	[65-68]	Increased expression causes decreased chemosensitivity
miR-153	[69]	Up regulation, increased resistance to oxaliplatin and cisplatin
miR-19a	[70]	Up regulation leads to resistance of FOLFOX therapy
miR-106a	[71]	Up regulation leads to resistance of 5-FU and oxalilatin
miR-130b	[71]	Up regulation leads to resistance of 5-FU and oxalilatin
miR-484	[71]	Up regulation leads to resistance of 5-FU and oxalilatin
miR-129	[72]	Down regulation increases resistance to 5-FU, transfection of miRNA into existing cells increase cytotoxic effect 5-FU
miR-15b	[73]	Down regulation increases resistance to 5-FU
miR-1915	[74]	Down regulation decreases chemotherapy by modulating apoptotic pathway
miR-122	[75]	Down regulation increases resistant to 5-FU

5-FU: 5-fluorouracil.