Review
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 21, 2015; 21(27): 8284-8292
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8284
Table 1 Summary of miRNA and early detection
miRNA and early detectionSummary
Micro RNARef.
miR-135bNew article [12,23]Tumor initiation, progression
miR-106a[24,25]Improves sensitivity of FOBT
miR-431[29]Diagnosis of colorectal adenocarcinoma
miR-15b[29]Diagnosis of colorectal adenocarcinoma
miR-139-3p[29]Diagnosis of colorectal adenocarcinoma
miR-532-3p[29]Diagnosis of colorectal adenocarcinoma
miR-331[29]Diagnosis of colorectal adenocarcinoma
miR-195[29]Diagnosis of colorectal adenocarcinoma
miR-17[29]Diagnosis of colorectal adenocarcinoma
miR-142-3p[29]Diagnosis of colorectal adenocarcinoma
miR-15b[29]Diagnosis of colorectal adenocarcinoma
miR-532[29]Diagnosis of colorectal adenocarcinoma
miR-652[29]Diagnosis of colorectal adenocarcinoma
miR193a-3p[30]Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-23a[30]Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-338-5p[30]Diagnosis of colorectal adenocarcinoma, expression levels in tumor
miR-18a[32]Diagnosis of colorectal adenocarcinoma
miR-20a[32]Diagnosis of colorectal adenocarcinoma
miR-21[32]Diagnosis of colorectal adenocarcinoma
miR-29a[32]Diagnosis of colorectal adenocarcinoma
miR-92a[32]Diagnosis of colorectal adenocarcinoma
miR-106b[32]Diagnosis of colorectal adenocarcinoma
miR-133a[32]Diagnosis of colorectal adenocarcinoma
miR-143[32]Diagnosis of colorectal adenocarcinoma
miR-145[32]Diagnosis of colorectal adenocarcinoma
miR-1288[33,34]Control for miRNA in colorectal cancer
FOBT: Fecal occult blood testing.
Table 2 Summary of miRNA and prognosis
miRNA and prognosisSummary
Micro RNARef.
miR-200c[35-38]Increased expression level predicts worse prognosis
miR-378[46]Potential prognostic biomarker
miR-126[47]Potential prognostic biomarker
miR-224[48,49]Potential prognostic biomarker
miR-429[50]Potential prognostic biomarker
miR-182[51]Potential prognostic biomarker
mir-32[52]Potential prognostic biomarker
miR-214[53]Potential prognostic biomarker
miR-182[54]Potential prognostic biomarker
miR-92a[55]Potential prognostic biomarker
miR-124[56]Potential prognostic biomarker
miR-30b[57]Potential prognostic biomarker
miR-625[58]Potential prognostic biomarker
miR-155[37]Potential prognostic biomarker
miR-210[37]Potential prognostic biomarker
miR-215[59]Potential prognostic biomarker
miR-130b[60]Potential prognostic biomarker
miR-148b[61]Potential prognostic biomarker
miR-148[61]Potential prognostic biomarker
miR-16[62]Potential prognostic biomarker
miR-21[10,39-45,47,65-68]Upregulated in CRC, associated with tumor size, distant metastasis, poor survival and independent biomarker
CRC: Colorectal cancer.
Table 3 Summary of miRNA and chemosensitivity
miRNA and chemosensitivitySummary
Micro RNARef.
miR-21[65-68]Increased expression causes decreased chemosensitivity
miR-153[69]Up regulation, increased resistance to oxaliplatin and cisplatin
miR-19a[70]Up regulation leads to resistance of FOLFOX therapy
miR-106a[71]Up regulation leads to resistance of 5-FU and oxalilatin
miR-130b[71]Up regulation leads to resistance of 5-FU and oxalilatin
miR-484[71]Up regulation leads to resistance of 5-FU and oxalilatin
miR-129[72]Down regulation increases resistance to 5-FU, transfection of miRNA into existing cells increase cytotoxic effect 5-FU
miR-15b[73]Down regulation increases resistance to 5-FU
miR-1915[74]Down regulation decreases chemotherapy by modulating apoptotic pathway
miR-122[75]Down regulation increases resistant to 5-FU
5-FU: 5-fluorouracil.