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©The Author(s) 2015.
World J Gastroenterol. Jul 21, 2015; 21(27): 8271-8283
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8271
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8271
Table 1 Breast cancer studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Gordon et al[50] | Therasphere | Breast (75) | RECIST and PET | RECIST | 6.6 mo |
(8/2014 Epub, RS) | (mean 1.52 Gbq) | @ 1.4 mo (median) | 24 (35.3) PR | ||
43 (63.2) SD | |||||
1 (1.5) PD | |||||
7 lost | |||||
PET | |||||
3 (12) CR | |||||
18 (72) PR or SD | |||||
4 (16) PD | |||||
50 lost | |||||
Seyal et al[48] | Unspecified | Breast (21) | RECIST 1.1 | 34 lesions | None |
(8/2014, RS) | (no dosage info) | 34 lesions | @ unspecified | 6 (17.7) PR | |
27 (79.4) SD | |||||
1 (2.9) PD | |||||
Saxena et al[47] | SIR-Spheres | Breast (40) | RECIST | 2 (5) CR | 13.6 mo |
(12/2013, RS) | (mean 1.67 Gbq) | @ 1 mo | 10 (26) PR | ||
15 (39) SD | |||||
11 (29) PD | |||||
2 lost | |||||
Cianni et al[33] | SIR-Spheres | Breast (77) | RECIST and PET | 29 (56) PR | 11.5 mo |
(1/2013, RS) | (median 1.9 Gbq) | @ 1.8 mo | 18 (35) SD | ||
5 (10) PD | |||||
25 ineligible | |||||
Jakobs et al[39] | SIR-Spheres | Breast (30) | RECIST | 14 (61) PR | 11.7 mo (all) |
(5/2008, PC) | (mean 1.9 Gbq) | @ 4.2 mo (median) | 8 (35) SD | 23.6 mo (responders) | |
1 (4) PD | 5.7 mo (nonresponders) | ||||
7 lost | |||||
Coldwell et al[35] | SIR-Spheres | Breast (44) | RECIST and PET | RECIST | Median OS not reached |
(3/2007, RS) | (median 2.1 Gbq) | @ 2.8 mo | 17 (47) PR | ||
17 (47) SD | 86% 14-mo survival | ||||
2 PD (5) PD | |||||
8 lost | |||||
PET scans | |||||
42 (95) response | |||||
2 (5) no response/progression | |||||
Bangash et al[31] | Therasphere | Breast (27) | WHO and PET | WHO | Median OS not given. |
(5/2007, PC) | (median 1.70 Gbq, mean 2.05 Gbq) | @ 3 mo | 9 (39.1) CR/PR | 6.8 mo (ECOG 0) | |
12 (52.1) SD | 2.6 mo (ECOG 1,2,3) | ||||
2 (8.8) PD 4 lost | 9.4 mo (< 25% tumor burden) | ||||
PET 17 (63) response | 2.0 mo (> 25% tumor burden) | ||||
10 (37) no response | |||||
Cianni et al[34] | SIR-Spheres | Breast (32, data extracted from larger study) | RECIST | 14 (44) CR/PR | None |
(1/2010, RS) | (mean 1.64 Gbq) | @ 1.8 mo | 11 (34) SD | ||
7 (22) PD | |||||
Reiner et al[46] | SIR-Spheres | Breast (1, data extracted from larger study) | RECIST 1.1 | 1 (100) CR/PR | None |
(1/2014, PC) | (mean 1.5 Gbq) | @ 4 mo | |||
Pöpperl et al[45] | SIR-Spheres | Breast (4, data extracted from larger study) | PET | 3 (100) Regression | None |
(4/2005, PC) | (mean 2.27 Gbq) | @ 3 mo | 1 lost |
Table 2 Cholangiocarcinoma studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Ibrahim et al[69] | Therasphere | ICC (24) | WHO | 6 (27) PR | 14.9 mo |
(10/2008, PC) | (median 105.1 Gy) | @ 1 mo | 15 (68) SD | ||
1 (5) PD | 31.8 mo (solitary) | ||||
2 lost | 6.1 mo (extrahepatic disease) | ||||
Saxena et al[71] | SIR-Spheres | ICC (25) | RECIST | 6 (26) PR | 9.3 mo |
(2/2010, PC) | (mean 1.76 Gbq) | @ 8.1 mo (median) | 11 (48) SD | ||
5 (22) PD | |||||
2 lost | |||||
Haug et al[68] | SIR-Spheres | ICC (26) | RECIST | 5 (22) PR | 11.7 mo |
(6/2011, PC) | (no dosage info) | @ 2.8 mo | 15 (65) SD | ||
3 (13) PD | |||||
3 lost | |||||
Hoffmann et al[3] | SIR-Spheres | ICC (33) | RECIST | 12 (36) PR | 22 mo |
(2/2012, RS) | (median 1.54 Gbq) | @ 3 mo | 17 (52) SD | ||
4 (12) PD | |||||
Rafi et al[70] | SIR-Spheres | ICC (19) | RECIST | 2 (11) PR | 11.5 mo |
(4/2013, PC) | (mean 1.20 Gbq) | @ 3 mo | 13 (68) SD | ||
4 (21) PD | |||||
Mouli et al[74] | Therasphere | ICC (46) | WHO | 11 (25) PR | No median OS |
(8/2013, PC) | (no dose info) | Note: overlaps with Ibrahim et al | @ 1 mo | 33 (73) SD 1 (2) PD | 14.6 mo (solitary) 5.7 mo (multifocal) |
Camacho et al[72] | SIR-Spheres | ICC (21) | RECIST | RECIST | 16.3 mo |
(2/2014, PC) | (no dose info) | mRECIST | 1 (4.7) PR | ||
EASL | 16 (76.2) SD | ||||
@ 1 mo | 4 (19.1) PD | ||||
mRECIST | |||||
13 (62.0) PR | |||||
4 (19.0) SD | |||||
4 (19.0) PD | |||||
EASL | |||||
2 (9.5) PR | |||||
15 (71.4) SD | |||||
4 (19.1) PD | |||||
Filippi et al[73] | SIR-Spheres | ICC (18) | PERCIST | 14 (82.3) PR | 14.8 mo |
(8/2014, PC) | (not given) | @ unspecified | 3 (17.6) SD |
Table 3 Melanoma studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage) | @ 1st assessment | |||
Xing et al[49] | SIR-Spheres | Melanoma (28) | RECIST 1.1 | 5/28 (21) PR | 10.1 mo |
(8/2014, RS) | (mean 1.86 Gbq) | 13 cutaneous | @ 0.9-1.4 mo | 9/28 (38) SD | |
15 ocular | 10/28 (42) PD | ||||
4 lost | |||||
Memon et al[42] | Therasphere | Melanoma (16) | WHO, RECIST, and EASL | WHO | 7.6 mo |
(6/2014, RS) | (median 1.87 Gbq) | 7 ocular | @ 0.9 mo | 5 (31) CR/PR | |
3 rectal | 8 (50) SD | ||||
4 cutaneous | 3 (19) PD | ||||
2 unknown | RECIST | ||||
5 (31) CR/PR | |||||
8 (50) SD | |||||
3 (19) PD | |||||
EASL | |||||
6 (38) CR/PR | |||||
7 (43) SD | |||||
3 (19) PD | |||||
Gonsalves et al[37] | SIR-Spheres | Ocular melanoma (32) | RECIST 1.0 | 1 (3) CR | 10.0 mo |
(2/2011, RS) | (median 1.08 Gbq) | @ 1 mo | 1 (3) PR | ||
18 (56) SD | |||||
12 (38) PD | |||||
Kennedy et al[40] | SIR-Spheres | Ocular melanoma (11) | RECIST | 1 (11) CR | Median OS not reached |
(7/2009, RS) | (median 1.55 Gbq) | @ 1.4 mo | 6 (66) PR | ||
1 (11) SD | |||||
1 (11) PD | |||||
2 lost | |||||
Reiner et al[46] | SIR-Spheres | Melanoma (2, data extracted from larger study) | RECIST 1.1 | 1 (50) CR/PR | None |
(1/2014, PC) | (mean 1.5 Gbq) | @ 4 mo | 1 (50) SD/PD | ||
Lim et al[41] | SIR-Spheres | Ocular melanoma (1, data extracted from larger study) | RECIST | 1 (100) PD | None |
(4/2005, PC) | (no dosage info) | @ 2 mo |
Table 4 Pancreatic cancer studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Michl et al[43] | SIR-Spheres | Pancreatic (19) | RECIST | 9/13 (64.3) PR | 9 mo |
(12/2013, RS) | (1.0-2.5 Gbq) | @ 2.6 mo (median) | 4/13 (35.7) PD | ||
6 lost | |||||
Cao et al[32] | SIR-Spheres | Pancreatic (7) | RECIST | 2 (40) PR | No median OS |
(11/2010, RS) | (no dosage info) | @ 1-2 mo | 1 (20) SD | 1 patient survived to 15 mo | |
2 (40) PD | |||||
2 lost | |||||
Pöpperl et al[45] | SIR-Spheres | Pancreatic (1, data extracted from larger study) | PET | 1 (100) Regression | None |
(4/2005, PC) | (mean 2.27 Gbq) | @ 3 mo |
Table 5 Renal cell carcinoma studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Abdelmaksoud et al[30] | SIR-Spheres | RCC (6) | mRECIST | 3 CR (60) | 12 mo |
(3/2012, RS) | (median 1.89 Gbq) | @ 25 mo (mean) | 1 PR (20) | ||
1 PD (20) | |||||
1 lost | |||||
Hamoui et al[38] | Therasphere | RCC (1) | Unspecified | 1 (100) SD | Patient died 23 mo after SIRT |
(2/2013, case report) | (80 Gy) | @ 1.8 mo |
Table 6 Lung or thoracic cancer studies n (%)
Author | Type of microsphere | Type of mets (patients) | Response criteria | Response | Median OS |
(publish date and study type) | (average dosage or activity) | @ 1st assessment | |||
Gaba et al[36] | Therasphere | Squamous cell lung cancer (2) | PET CT | 2 (100) CR | Patient 1: Alive 11 mo after SIRT |
(8/2012, case report) | (1.57-3 Gbq) | @ 2-3 mo | Patient 2: Alive 2 mo after SIRT | ||
Murthy et al[44] | SIR-Spheres | Lung cancer (6) | Unspecified | 1 (17) PR | 2.7 mo |
(2/2008, RS) | (no dosage info) | 2 carcinoids 3 adenocarcinomas | @ unspecified | 1 (17) “minor response” | |
1 small cell carcinoma | 1 (17) SD | ||||
3 (50) PD | |||||
Reiner et al[46] | SIR-Spheres | NSCLC (1, data extracted from larger study) | RECIST 1.1 | 1 (100) CR/PR | None |
(1/2014, PC) | (mean 1.5 Gbq) | @ 4 mo |
- Citation: Kuei A, Saab S, Cho SK, Kee ST, Lee EW. Effects of Yttrium-90 selective internal radiation therapy on non-conventional liver tumors. World J Gastroenterol 2015; 21(27): 8271-8283
- URL: https://www.wjgnet.com/1007-9327/full/v21/i27/8271.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i27.8271