Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer

Table 1 Correlation between NADPH oxidase 2 expression and clinical-pathological characters in gastric cancer n (%)

Clinical feature	Total number (n = 123)	NOX2 positivity negativity	χ2-value	P-value
Gender
Male	69	30 (43.5)	0.852	0.229
		39 (56.5)
Female	54	28 (51.9)
		26 (48.1)
Age (yr)
< 59	55	27 (49.1)	0.150	0.419
		28 (50.9)
≥ 59	68	31 (45.6)
		37 (54.4)
Position
Cardia and fundus	30	8 (26.6)	6.683	0.008
		22 (73.3)
Body and antrum	93	50 (53.8)
		43 (46.2)
Differentiation type
High	22	6 (27.3)	5.062	0.042
		16 (72.7)
Moderate	34	16 (47.1)
		18 (52.9)
Poor	62	34 (54.8)
		28 (45.2)
Undifferentiation	5	2 (40)
		3 (60)
Lymph node metastasis
Yes	53	34 (64.2)	10.796	0.001
		19 (35.8)
No	70	24 (34.3)
		46 (65.7)
Vascular invasion
Yes	60	35 (58.3)	5.875	0.012
		25 (41.7)
No	63	23 (36.5)
		40 (63.5)
Clinical stage
Early stage	32	9(28.1)	6.285	0.010
		23(71.9)
Advanced stage	91	49(53.8)
		42(46.2)
TNM
I + II	35	10(28.6)	6.779	0.008
		25(71.4)
III + IV	88	48(68.6)
		40(31.4)

NOX2: NADPH oxidase 2.

Table 2 Univariate analysis of clinicopathological features for the prognosis in 123 gastric cancer patients

Variable	Coef	SE	Wald	RR value (95%CI)	P-value
Clinical stage	0.531	0.221	5.7970	1.701 (1.104-2.620)	0.016
Differentiation type	0.363	0.193	3.5250	1.438 (0.984-2.101)	0.060
Lymph node metastasis	0.971	0.213	20.857	0.379 (0.250-0.575)	0.000
Vascular invasion	0.926	0.198	21.854	0.396 (0.269-0.584)	0.000
TNM	0.638	0.214	8.9030	1.892 (1.245-2.876)	0.003
NOX2	1.080	0.212	26.004	0.339 (0.224-0.514)	0.000

NOX2: NADPH oxidase 2.

Table 3 Multivariate analysis of clinicopathological features for the prognosis in 123 gastric cancer patients

Variable	Coef	SE	Wald	RR value (95%CI)	P-value
Clinical stage	0.670	0.236	8.0800	1.955 (1.230-3.103)	0.004
Differentiation type	0.176	0.201	0.7710	1.193 (0.805-1.769)	0.380
Lymph node metastasis	0.760	0.232	10.725	0.468 (0.297-0.737)	0.001
Vascular invasion	1.061	0.220	23.330	0.346 (0.225-0.532)	0.000
TNM	0.519	0.229	5.1360	0.637 (0.406-0.999)	0.049
NOX2	0.824	0.236	12.153	0.439 (0.276-0.697)	0.000

NOX2: NADPH oxidase 2.