Emerging concepts in liver graft preservation

Table 1 Additives for improving static cold storage in University of Wisconsin and Institute Georges Lopez preservation solutions

Additive	Preservation solution	Ref.
TMZ	UW, IGL-1	[25,30]
EGF + IGF-1	UW	[45]
IGF-1	IGL-1	[44]
EGF	IGL-1	[46]
ML	IGL-1	[43]
BZ	UW, IGL-1	[51,117]
SV	UW	[64]
BZ, MG132	UW	[50]
ML + TMZ	IGL-1	[38]
CAII	IGL-1	[54]

TMZ: Trimetazidine; EGF: Endothelial growth factor; IGF: Insulin growth factor 1; ML: Melatonin; BZ: Bortezomib; SV: Simvastatin; CAII: Carbonic anhydrase II; UW: University of Wisconsin; IGL-1: Institute Georges Lopez.

Table 2 Advantages and disadvantages of machine perfusion preservation

Advantages	Disadvantages
Continuous nutrients and oxygen supply	Logistically complex
Continuous monitoring of organ viability	High cost
Removal of metabolic waste products	No optimized conditions
Extended preservation time	Need for trained personnel
Better preservation of microcirculation
Potential “rescue” of suboptimal organs