Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed

Table 1 Classification of sphincter of Oddi dysfunction

	Abnormal liver or pancreatic chemistries	Biliary or pancreatic duct dilation on imaging
Type I	Both	Both
Type II	Either	Either
Type III	Neither	Neither

Table 2 Randomised controlled trials’s of Type II sphincter of Oddi dysfunction n (%)

	Geenen (’89)	Toouli (2000)
Rome type 3	-	-
Concealed assignment	?	+
Blinded f/u	Yes	Yes
Type I	0	0
Type II	47 (100)	81 (100)
Type III	0	0
Sham EBS	Yes	Yes
Mano Directed	No	Yes
Response
+ mano (EBS vs S)	91%, 25%	85%, 38%
- Mano (EBS vs S)	33%, 42%	62%, 42%

F/U: Follow-up; EBS: Endoscopic biliary sphincterotomy; mano: Manometry; S: Sham.