Copyright
©The Author(s) 2015.
World J Gastroenterol. May 14, 2015; 21(18): 5707-5718
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5707
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5707
Table 1 Characteristics of the included studies focusing on IL-17 genetic polymorphisms
Ref. | Year | Country | Sample size | Gender (M/F) | Age (yr) | Genotyping methods | Gene | SNP | STROBE | |||
Case | Control | Case | Control | Case | Control | |||||||
Wu et al[30] | 2014 | China | 945 | 768 | - | - | - | - | PCR-RFLP | IL-17A | rs2275913 G>A | 29 |
Zhang et al[23] | 2014 | China | 260 | 512 | 162/98 | 280/232 | 60.6 ± 10.7 | 51.3 ± 11.2 | Sequenom MassArray | IL-17A | rs2275913 G>A | 30 |
rs763780 T>C | ||||||||||||
Zhu et al[2] | 2014 | China | 293 | 550 | 189/104 | 312/238 | 57.5 ± 11.3 | 56.7 ± 12.7 | Sequenom MassArray | IL-17A | rs2275913 G>A | 31 |
IL-17F | rs763780 T>C | |||||||||||
Rafiei et al[7] | 2013 | Iran | 161 | 171 | 89/72 | 84/87 | 62.6 ± 12.4 | 60.8 ± 12.8 | PCR-RFLP | IL-17A | rs2275913 G>A | 27 |
Arisawa et al[29] | 2012 | China | 337 | 587 | 234/103 | 314/273 | 65.3 ± 11.4 | 61.4 ± 13.7 | PCR-SSCP | IL-17A | rs2275913 G>A | 33 |
Zeng et al[31] | 2010 | China | 927 | 777 | - | - | - | - | PCR-RFLP | IL-17F | rs763780 T>C | 29 |
Shibata et al[20] | 2009 | Japan | 287 | 524 | 203/84 | 307/217 | 65.0 ± 11.8 | 55.7 ± 18.3 | PCR-SSCP | IL-17A | rs2275913 G>A | 32 |
IL-17F | rs763780 T>C |
Table 2 Meta-analysis of the association between IL-17 genetic polymorphisms and gastric cancer
Subgroup analysis | W allele vs M(Allele model) | WW + WM vs MM(Dominant model) | WW vs WM + MM(Recessive model) | WW vs MM(Homozygous model) | WW vs WM(Heterozygous model) | ||||||||||
OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | P value | |
rs2275913 G>A | 1.33 | 1.12-1.57 | 0.001 | 1.34 | 1.11-1.62 | 0.003 | 1.50 | 1.15-1.94 | 0.002 | 1.65 | 1.23-2.20 | 0.001 | 1.42 | 1.10-1.84 | 0.008 |
Country | |||||||||||||||
China | 1.47 | 1.05-2.05 | 0.024 | 1.59 | 1.19-2.11 | 0.001 | 1.60 | 0.95-2.70 | 0.078 | 1.98 | 1.12-3.50 | 0.019 | 1.43 | 0.86-2.38 | 0.167 |
Iran | 1.22 | 0.90-1.65 | 0.207 | 1.07 | 0.66-1.73 | 0.788 | 1.49 | 0.93-2.39 | 0.095 | 1.39 | 0.79-2.44 | 0.258 | 1.57 | 0.94-2.63 | 0.087 |
Japan | 1.19 | 1.04-1.37 | 0.013 | 1.12 | 0.89-1.40 | 0.322 | 1.37 | 1.11-1.70 | 0.004 | 1.36 | 1.04-1.77 | 0.022 | 1.38 | 1.10-1.74 | 0.006 |
Genotyping method | |||||||||||||||
PCR-RFLP | 1.11 | 0.98-1.26 | 0.088 | 1.24 | 1.02-1.52 | 0.034 | 1.15 | 0.79-1.69 | 0.468 | 1.23 | 0.97-1.57 | 0.088 | 1.13 | 0.67-1.93 | 0.644 |
MassArray | 1.72 | 1.48-2.00 | < 0.001 | 1.85 | 1.43-2.41 | < 0.001 | 2.06 | 1.66-2.56 | < 0.001 | 2.61 | 1.95-3.49 | < 0.001 | 1.83 | 1.45-2.32 | < 0.001 |
PCR-SSCP | 1.19 | 1.04-1.37 | 0.013 | 1.12 | 0.89-1.40 | 0.322 | 1.37 | 1.11-1.70 | 0.004 | 1.36 | 1.04-1.77 | 0.022 | 1.38 | 1.10-1.74 | 0.006 |
rs763780 T>C | 1.95 | 1.47-2.59 | < 0.001 | 1.21 | 0.85-1.72 | 0.299 | 2.47 | 1.63-3.74 | < 0.001 | 1.54 | 1.15-2.05 | 0.004 | 2.83 | 1.63-4.91 | < 0.001 |
Country | |||||||||||||||
China | 1.85 | 1.32-2.59 | < 0.001 | 1.13 | 0.84-1.54 | 0.421 | 2.42 | 1.40-4.18 | 0.002 | 1.45 | 1.07-1.95 | 0.016 | 2.93 | 1.34-6.39 | 0.007 |
Japan | 2.31 | 1.71-3.12 | < 0.001 | 2.60 | 0.88-7.72 | 0.085 | 2.68 | 1.91-3.75 | < 0.001 | 3.44 | 1.15-10.26 | 0.027 | 2.62 | 1.86-3.70 | < 0.001 |
Genotyping method | |||||||||||||||
PCR-RFLP | 1.40 | 1.19-1.66 | < 0.001 | 1.40 | 0.91-2.14 | 0.122 | 1.51 | 1.24-1.84 | < 0.001 | 1.60 | 1.04-2.46 | 0.033 | 1.50 | 1.21-1.85 | < 0.001 |
MassArray | 2.17 | 1.78-2.66 | < 0.001 | 0.94 | 0.62-1.41 | 0.759 | 3.14 | 2.45-4.01 | < 0.001 | 1.32 | 0.87-1.99 | 0.194 | 4.20 | 3.14-5.62 | < 0.001 |
PCR-SSCP | 2.31 | 1.71-3.12 | < 0.001 | 2.60 | 0.88-7.72 | 0.085 | 2.68 | 1.91-3.75 | < 0.001 | 3.44 | 1.15-10.26 | 0.027 | 2.62 | 1.86-3.70 | < 0.001 |
Table 3 Univariate and multivariate meta-regression analyses of the potential source of heterogeneity
Heterogeneity factors | rs2275913 G>A | rs763780 T>C | ||||||||||
Coefficient | SE | Z | P value | 95%CI | Coefficient | SE | Z | P value | 95%CI | |||
LL | UL | LL | UL | |||||||||
Publication year | ||||||||||||
Univariate | 0.042 | 0.048 | 0.87 | 0.386 | -0.053 | 0.137 | 0.034 | 0.065 | 0.52 | 0.601 | -0.093 | 0.161 |
Multivariate | 0.040 | 0.030 | 1.32 | 0.185 | -0.019 | 0.098 | -0.093 | 0.056 | -1.67 | 0.094 | -0.202 | 0.016 |
Country | ||||||||||||
Univariate | -0.119 | 0.123 | -0.97 | 0.332 | -0.360 | 0.121 | 0.225 | 0.335 | 0.67 | 0.502 | -0.432 | 0.882 |
Multivariate | 0.035 | 0.087 | 0.41 | 0.684 | -0.135 | 0.206 | 0.279 | 0.167 | 1.67 | 0.094 | -0.048 | 0.606 |
Genotyping method | ||||||||||||
Univariate | -0.209 | 0.049 | -4.27 | 0.000 | -0.305 | -0.113 | -0.216 | 0.091 | -2.36 | 0.018 | -0.395 | -0.037 |
Multivariate | -0.218 | 0.051 | -4.31 | 0.000 | -0.317 | 0.119 | -0.219 | 0.067 | -3.27 | 0.001 | -0.350 | -0.087 |
-
Citation: Long ZW, Yu HM, Wang YN, Liu D, Chen YZ, Zhao YX, Bai L. Association of
IL-17 polymorphisms with gastric cancer risk in Asian populations. World J Gastroenterol 2015; 21(18): 5707-5718 - URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5707.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5707