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©The Author(s) 2015.
World J Gastroenterol. May 14, 2015; 21(18): 5668-5676
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5668
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5668
Table 1 Individual factors of patients with diverse responses at 52 wk after interferon-α therapy n (%)
Characteristic | Total (n = 147) | RS (n = 47) | NRS (n = 100) |
Sex | |||
Male | 106 (72.1) | 33 (70.2) | 73 (73.0) |
Female | 41 (27.9) | 14 (29.8) | 27 (27.0) |
Age (yr) | 25.02 ± 056 | 26.40 ± 1.19 | 24.37 ± 0.59 |
ALT (U/L) | 214.25 ± 17.38 | 226.23 ± 19.19 | 208.62 ± 23.94 |
HBV DNA | |||
(log10 copies/mL) | 7.16 ± 0.07 | 6.93 ± 0.14 | 7.27 ± 0.09 |
HBsAg | |||
(log10 IU/mL) | 4.11 ± 0.07 | 3.93 ± 0.14 | 4.20 ± 0.07 |
HBeAg | |||
(log10 S/CO) | 2.55 ± 0.07 | 2.30 ± 0.13a | 2.67 ± 0.07a |
Anti-HBc (S/CO) | 11.13 ± 0.15 | 11.54 ± 0.27 | 10.94 ± 0.17 |
Genotype | |||
B | 85 (57.8) | 26 (55.3) | 59 (59.0) |
C | 55 (37.4) | 21 (44.7) | 34 (34.0) |
Other | 7 (4.8) | 0 (0.0) | 7 (7.0) |
Table 2 Factors at baseline influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)
Parameter | RS | Univariate analysis | P value | Multivariate analysis | P value |
OR (95%CI) | OR (95%CI) | ||||
Female gender | 14 (34.1) | 1.15 (0.53-2.47) | 0.725 | ||
Age > 24 yr | 26 (40.0) | 1.94 (0.96-3.91) | 0.065 | ||
ALT > 4 × ULN | 33 (44.6) | 3.39 (1.62-7.12) | 0.001 | 2.44 (1.10-5.42) | 0.028 |
HBV DNA ≤ 7 | |||||
log10 copies/mL | 22 (39.3) | 1.71 (0.84-3.46) | 0.138 | ||
HBsAg ≤ 15000 IU/mL | 27 (40.3) | 2.03 (1.00-4.09) | 0.049 | ||
HBeAg ≤ 500 S/CO | 26 (47.3) | 3.03 (1.48-6.22) | 0.003 | 2.12 (0.97-4.64) | 0.060 |
anti-HBc > 11.4 S/CO | 33 (45.8) | 3.69 (1.75-7.75) | 0.001 | 3.02 (1.39-6.57) | 0.005 |
Genotype B | 26 (30.6) | 0.91 (0.50-1.65) | 0.749 |
Table 3 Factors at 12 wk influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)
Parameter | RS | Univariate analysis | P value | Multivariate analysis | P value |
OR (95%CI) | OR (95%CI) | ||||
ALT > 7 × ULN | 8 (61.5) | 3.90 (1.20-12.66) | 0.024 | ||
HBV DNA ≤ 5 log10 copies/mL | 31 (53.4) | 5.24 (2.48-11.06) | < 0.001 | ||
HBsAg ≤ 10000 IU/mL | 41 (48.2) | 8.70 (3.39-22.34) | < 0.001 | ||
HBeAg ≤ 250 S/CO | 44 (55.7) | 27.24 (7.89-94.09) | < 0.001 | 10.90 (2.63-45.27) | 0.001 |
anti-HBc > 11.8 S/CO | 23 (47.9) | 2.88 (1.39-5.96) | 0.005 | 3.72 (1.41-9.84) | 0.008 |
Decline ALT > 3 × ULN | 20 (40.0) | 1.73 (0.84-3.55) | 0.136 | ||
Decline HBV DNA > 1.5 log10 copies/mL | 34 (48.6) | 4.65 (2.18-9.93) | < 0.001 | ||
Decline HBsAg > 0.5 log10 IU/mL | 29 (55.8) | 5.39 (2.55-11.42) | < 0.001 | ||
Decline HBeAg > 1 log10 S/CO | 34 (66.7) | 12.77 (5.60-29.14) | < 0.001 | 4.53 (1.59-12.91) | 0.005 |
Decline anti-HBc > 0.5 S/CO | 13 (40.6) | 1.64 (0.53-5.07) | 0.393 |
Table 4 Factors at 24 wk influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)
Parameter | RS | Univariate analysis | P value | Multivariate analysis | P value |
OR (95%CI) | OR (95%CI) | ||||
ALT ≤ 1 × ULN | 25 (45.5) | 2.65 (1.30-5.42) | 0.008 | ||
HBV DNA ≤ 4 log10 copies/mL | 32 (50.8) | 4.48 (2.25-10.01) | < 0.001 | ||
HBsAg ≤ 2000 IU/mL | 33 (52.4) | 5.50 (2.58-11.73) | < 0.001 | ||
HBeAg ≤ 5 S/CO | 41 (65.1) | 24.23 (9.11-64.47) | < 0.001 | 16.82 (5.07-55.79) | < 0.001 |
anti-HBc > 11.4 S/CO | 30 (44.8) | 3.01 (1.46-6.18) | 0.003 | 3.01 (1.20-7.56) | 0.019 |
Decline ALT > 2 × ULN | 35 (42.2) | 3.16 (1.47-6.78) | 0.003 | ||
Decline HBV DNA > 2 log10 copies/mL | 36 (46.8) | 4.71 (2.15-10.32) | < 0.001 | ||
Decline HBsAg > 1 log10 IU/mL | 26 (49.1) | 3.35 (1.62-6.91) | 0.001 | ||
Decline HBeAg > 2 log10 S/CO | 30 (66.7) | 10.00 (4.45-22.47) | < 0.001 | 1.85 (0.62-5.49) | 0.269 |
Decline anti-HBc > 0.5 S/CO | 19 (47.5) | 2.55 (1.20-5.43) | 0.015 |
- Citation: Wang CT, Zhang YF, Sun BH, Dai Y, Zhu HL, Xu YH, Lu MJ, Yang DL, Li X, Zhang ZH. Models for predicting hepatitis B e antigen seroconversion in response to interferon-α in chronic hepatitis B patients. World J Gastroenterol 2015; 21(18): 5668-5676
- URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5668.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5668