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©The Author(s) 2015.
World J Gastroenterol. May 14, 2015; 21(18): 5591-5597
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5591
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5591
Table 1 Clinicopathological features according to neutrophil-lymphocyte ratio n (%)
Variable | NLR | |||
Cases | ≤3.0 | > 3.0 | P value1 | |
Age (yr) | 0.112 | |||
≤ 57.02 | 201 (54.2) | 167 (83.1) | 34 (16.9) | |
> 57.0 | 170 (45.8) | 130 (76.5) | 40 (23.5) | |
Sex | 0.562 | |||
Female | 95 (25.6) | 78 (82.1) | 17 (17.9) | |
Male | 276 (74.4) | 219 (79.3) | 57 (20.7) | |
Location | 0.372 | |||
Upper | 23 (6.2) | 19 (82.6) | 4 (17.4) | |
Middle | 256 (69.0) | 200 (78.1) | 56 (21.9) | |
Lower | 92 (24.8) | 78 (84.8) | 14 (15.2) | |
Differentiation | 0.487 | |||
Well | 58 (15.6) | 46 (79.3) | 12 (20.7) | |
Moderate | 245 (66.0) | 193 (78.8) | 52 (21.2) | |
Poor | 68 (18.3) | 58 (85.3) | 10 (14.7) | |
pT status | 0.007 | |||
T1 | 17 (4.6) | 15 (88.2) | 2 (11.8) | |
T2 | 88 (23.7) | 80 (90.9) | 8 (9.1) | |
T3 | 266 (71.7) | 202 (75.9) | 64 (24.1) | |
pN status | 0.592 | |||
N0 | 199 (53.6) | 163 (81.9) | 36 (18.1) | |
N1 | 102 (27.5) | 82 (80.4) | 20 (19.6) | |
N2 | 55 (14.8) | 41 (74.5) | 14 (25.5) | |
N3 | 15 (4.0) | 11 (73.3) | 4 (26.7) | |
Stage | 0.566 | |||
IB | 20 (5.4) | 17 (85.0) | 3 (15.0) | |
IIA | 58 (15.6) | 50 (86.2) | 8 (13.8) | |
IIB | 148 (39.9) | 119 (80.4) | 29 (19.6) | |
IIIA | 83 (22.4) | 66 (79.5) | 17 (20.5) | |
IIIB | 47 (12.7) | 34 (72.3) | 13 (27.7) | |
IIIC | 15 (4.0) | 11 (73.3) | 4 (26.7) | |
Total | 371 (100) | 297 (80.1) | 74 (19.9) |
Table 2 Univariate analysis of factors associated with recurrence-free survival and cancer-specific survival
Variable | Cases (n) | CSS (mo) | RFS (mo) | ||||
Mean | Median | P value | Mean | Median | P value | ||
Age (yr) | 0.259 | 0.230 | |||||
≤ 57.01 | 201 | 61.9 | 42 | 54.7 | 32 | ||
> 57.0 | 170 | 59.1 | 70 | 53.9 | 66 | ||
Sex | 0.070 | 0.113 | |||||
Female | 95 | 72.2 | NR | 62.3 | 74 | ||
Male | 276 | 59.5 | 45 | 52.8 | 34 | ||
Location | 0.033 | 0.127 | |||||
Upper | 23 | 70.4 | NR | 52.2 | 58 | ||
Middle | 256 | 52.7 | 41 | 48.8 | 35 | ||
Lower | 92 | 74.8 | NR | 67.5 | 74 | ||
Differentiation | 0.014 | 0.005 | |||||
Well | 58 | 55.0 | 55 | 52.1 | 58 | ||
Moderate | 245 | 67.9 | 70 | 59.0 | 65 | ||
Poor | 68 | 44.0 | 25 | 38.1 | 22 | ||
pT status | 0.003 | 0.008 | |||||
T1 | 17 | 60.5 | NR | 55.5 | NR | ||
T2 | 88 | 71.6 | 74 | 65.9 | 77 | ||
T3 | 266 | 59.4 | 39 | 51.1 | 29 | ||
pN status | < 0.001 | < 0.001 | |||||
N0 | 199 | 80.9 | NR | 71.7 | 87 | ||
N1 | 102 | 44.1 | 41 | 40.1 | 29 | ||
N2 | 55 | 25.0 | 15 | 21.2 | 10 | ||
N3 | 15 | 20.7 | 11 | 12.0 | 6 | ||
Stage | < 0.001 | < 0.001 | |||||
I | 20 | 64.1 | NR | 62.6 | NR | ||
II | 206 | 77.4 | NR | 68.3 | 85 | ||
III | 145 | 32.7 | 21 | 29.0 | 15 | ||
NLR | < 0.001 | 0.001 | |||||
≤ 3.0 | 297 | 68.3 | 70 | 61.0 | 58 | ||
> 3.0 | 74 | 41.2 | 24 | 38.3 | 17 |
Table 3 Results of multivariable cox regression analysis
Prognostic factor | HR | 95%CI | P value |
CSS | |||
Location (upper vs middle vs lower) | 0.888 | 0.677-1.164 | 0.389 |
Differentiation (well vs moderate vs poor) | 1.156 | 0.911-1.468 | 0.233 |
pT status ( T1 vs T2 vs T3) | 1.101 | 0.778-1.559 | 0.586 |
pN status (N0 vs N1 vs N2 vs N3) | 1.615 | 1.266-2.061 | < 0.001 |
Stage (I vs II vs III) | 1.460 | 0.907-2.351 | 0.120 |
NLR ( ≤ 3.0 vs > 3.0) | 1.591 | 1.132-2.235 | 0.007 |
RFS | |||
Differentiation (well vs moderate vs poor) | 1.177 | 0.934-1.482 | 0.167 |
pT status (T1 vs T2 vs T3) | 1.088 | 0.782-1.515 | 0.615 |
pN status (N0 vs N1 vs N2 vs N3) | 1.703 | 1.337-2.169 | < 0.001 |
Stage (I vs II vs III) | 1.336 | 0.846-2.110 | 0.215 |
NLR ( ≤ 3.0 vs > 3.0) | 1.525 | 1.094-2.126 | 0.013 |
Table 4 Univariate analysis of neutrophil-lymphocyte ratio stratified by tumor staging n (%)
TNM stage | Cases | P value | |
CSS | RFS | ||
IB | 20 (5.4) | 0.590 | 0.590 |
IIA | 58 (15.6) | 0.987 | 0.977 |
IIB | 148 (39.9) | 0.082 | 0.082 |
IIIA | 83 (22.4) | 0.008 | 0.008 |
IIIB | 47 (12.7) | 0.356 | 0.596 |
IIIC | 15 (4.0) | 0.440 | 0.700 |
- Citation: Duan H, Zhang X, Wang FX, Cai MY, Ma GW, Yang H, Fu JH, Tan ZH, Meng YQ, Fu XY, Ma QL, Lin P. Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma. World J Gastroenterol 2015; 21(18): 5591-5597
- URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5591.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5591