Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

doi:10.3748/wjg.v21.i14.4126

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Apr 14, 2015 (publication date) through Oct 31, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2015; 21(14): 4126-4135
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4126

Table 1 Splenic pulp pressure and abdominal aortic flow 7 d post portal vein ligation or sham

	Splenic pulp pressure (cmH₂O)	Abdominal aortic flow (mL/min per gram)
Wild type sham	6.9 ± 0.4	0.17 ± 0.02
Wild type 7 d PVL	25.4 ± 3.1^a	0.27 ± 0.04^a
eNOS^-/- sham	6.9 ± 0.3	0.15 ± 0.01
eNOS^-/- 7 d PVL	7 ± 0.5	0.15 ± 0.01
iNOS^-/- 7 d sham	6.7 ± 1	0.16 ± 0.01
iNOS^-/- 7 d PVL	21.1 ± 0.4^c	0.23 ± 0.06^c

^aP < 0.05 vs wild type sham t-test;

^cP < 0.05 vs iNOS^-/- 7d sham t-test; mean ± SE (n = 4-7). iNOS: Inducible nitric oxide synthase.

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Citation: Theodorakis NG, Wang YN, Korshunov VA, Maluccio MA, Skill NJ. Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure. World J Gastroenterol 2015; 21(14): 4126-4135
URL: https://www.wjgnet.com/1007-9327/full/v21/i14/4126.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i14.4126