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Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 3850-3859
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3850
Table 1 Randomized clinical trials comparing adjuvant chemoradiotherapy vs chemotherapy
Ref.TreatmentnDDFSOSToxicities G3-G4
Park et al[17]XP vs XP/XRT/XP458D20.74 (0.52-1.05)1.13 (0.77-1.64)N 12%, V 3% in both groups
Kim et al[19]FL/FL + RT/FL vs FL90D260.9% vs 50.0%65.2% vs 54.6%Hem 25%, GI 11.4% vs Hem 19.6%, GI 17.4%
Zhu et al[20]FL/FL + IMRT/FL vs FL404D21.35 (1.03-1.78)1.24 (0.94-1.65)Leuco 7.5%, N 2.7% vs Leuco 7.3%, N 0%
Table 2 Randomized clinical trials comparing adjuvant chemotherapy vs observation
StudyTreatmentnDDFSOSToxicities G3-G4
ACTS-GC[23,24]S-1 vs observation1059D2-30.65 (0.53-0.79)a0.66 (0.54-0.82)aAnorexia 6%, N 3.7%
CLASSIC[25]XELOX vs observation1035D20.56 (0.44-0.72)aNRLeuco 22%, N 8%
Table 3 Randomized clinical trials comparing perioperative chemotherapy vs observation
StudyTreatmentnDDFSOSToxicities G3-G4
MAGIC[28]ECF vs observation503D1-20.66 (0.53-0.81)a0.75 (0.60-0.93)aLeuco 27.8%, N 12.3%
ACCORD-07[30]CF vs observation224NR0.65 (0.48-0.89)a0.69 (0.50-0.95)aLeuco 20.2%, N 9.2%