Hepatectomy vs radiofrequency ablation for colorectal liver metastasis: A propensity score analysis

Table 1 Patient characteristics n (%)

	Hepatectomy	RFA	P
	n = 102	n = 51
Sex (M/F)	73/29	35/16	0.71
Age (years) median (range)	60 (3-79)	58.5 (35-79)	0.99
Preoperative CEA (ng/mL) median (range)	4.4 (0.1-202)	6.5 (0.9-144)	0.19
Size of liver metastases, median (range)	1.7 (0.2-3.0)	1.8 (1.0-3.0)	0.26
Number of liver metastasis
Single	63 (62)	29 (57)	0.56
Multiple	39 (38)	22 (43)
Metastasis type
Synchronous	76 (75)	33 (65)	0.21
Metachronous	26 (25)	18 (35)
Location of liver metastasis
Unilobal	80 (78)	38 (75)	0.59
Bilobal	22 (22)	13 (25)
N stage
N0	30 (29)	13 (25)	0.61
N1, N2	72 (71)	38 (75)
Location of primary colorectal cancer
Colon	53 (52)	29 (57)	0.57
Rectum	49 (48)	22 (43)
Histological differentiation1
High grade	88 (86)	45 (88)	0.73
Low grade	14 (14)	6 (12)
Comorbidity
Liver cirrhosis2	5 (5)	6 (12)	0.18
Diabetes mellitus	20 (20)	13 (25)	0.40
Hypertension	29 (28)	12 (24)	0.52
Cardiovascular disease	3 (3)	1 (2)	0.72
Pulmonary disease	6 (6)	2 (4)	0.99
Neoadjuvant chemotherapy
Yes	6 (6)	5 (10)	0.30
No	70 (94)	28 (90)
Adjuvant chemotherapy
Yes	95 (93)	46 (90)	0.54
No	7 (7)	5 (10)

¹High grade: well or moderately differentiated, Low grade: poorly differentiated or mucinous carcinoma;

²The grade of liver cirrhosis was Child-Pugh Class A in all 11 patients. RFA: Radiofrequency ablation; CEA: Carcinoembryonic antigen.

Table 2 Disease-free survival after surgical treatment with curative intent for colorectal liver metastasis by multivariate analysis by Cox regression proportional hazard model (n = 153)

Factors	Univariate analysis of DFS	Multivariate analysis of DFS
	P	HR	95%CI	P1
Radiofrequency ablation	0.033	1.57	1.02-2.41	0.040
Female sex	0.890
Age	0.270
CEA (ng/mL)	0.130	1.03	0.99-1.01	0.480
Size (cm)	0.210
Multiple	0.140	1.01	0.65-1.57	0.970
Metachronous	0.089	0.75	0.45-1.24	0.260
Bilobal	0.300
T22	0.130	0.55	0.18-1.65	0.290
T32	0.090	0.78	0.41-1.49	0.450
Lymph node metastasis	0.003	1.94	1.14-3.31	0.015
Adjuvant chemotherapy	0.810
Poorly differentiated grade	0.033	1.79	1.01-3.18	0.049

¹Cox regression proportional hazard model;

²Compared with T4 (T stage of primary colorectal tumor). CEA: Carcinoembryonic antigen; DFS: Disease-free survival; CRLM: Colorectal liver metastasis.