Cutaneous metastasis of cholangiocarcinoma

Table 1 Clinical features of patients with cutaneous metastasis of cholangiocarcinoma

Age (n = 30)	n (%)
Median at diagnosis (yr) 60.0
Range (yr) 35-77
30-40	2 (6.7)
41-50	6 (20.0)
51-59	6 (20.0)
60-70	9 (30.0)
> 70	7 (23.3)
Sex (n = 30)
Male	23 (76.7)
Female	7 (23.3)
Cutaneous metastasis occurrence (n = 30)
Before diagnosis of cholangiocarcinoma	8 (26.7)
After diagnosis of cholangiocarcinoma	21 (70.0)
Not available	1 (3.3)
Number of cutaneous metastasis throughout life (n = 30)
Single	18 (60.0)
Multiple	12 (40.0)
Sites of initial cutaneous metastasis (n = 30)
Drainage site	15 (50.0)
Distant site	15 (50.0)
Scalp1	11 (36.7)
Head2	2 (6.7)
Shoulder	1 (3.3)
Trunk	1 (3.3)

¹Including a case with initial skin metastasis of scalp and head and two cases with initial skin metastasis of scalp and trunk;

²Including a case with the initial skin metastasis on the head, face, and trunk.

Table 2 Immunohistochemical analysis of cutaneous metastasis in 9 cases

Case number	Immunohistochemistry results
1	CK7+, CEA-, CK20-
2	CK7+, CK19+
3	CK19+, CEA+
4	CK7+, CK8/18/19+, CEA+, CK20-
5	CK7+, CAM5.2+, AE1/3+, CK20-
6	CK7+, CK20+, CA199 (focally+), TTF1-
7	CK7+, CK19+
8	CK7 (strongly+), CK20 (weakly+)
9	CK7+, CK20+, p53+