Prognostic value of 18F-FDG PET/CT in liver transplantation for hepatocarcinoma

Table 1 Patients characteristics (n = 27)

Characteristics		mean ± SD or n	Ranges
Age (yr)		58 ± 10	29-72
Gender (Male/Female)		24/3
Underlying liver disease
	Alcohol	8
	Viral	15
	Other cirrhosis	2
	Non-cirrhotic liver	2
AFP at transplant (ng/mL)		199 ± 476	0.9-1957
Milan at listing	In/out	13/14
Neoadjuvant treatment	Yes/no	9/18
CHILD	A/B/C	9/10/8
OKUDA	I/II/III	7/15/5
CLIP	0/1/2/3/4	1/7/9/6/4
Pathology
Number of nodules	1/2/3/> 3	5/6/3/13
Size of largest lesion (cm)		3.8 ± 2.2	1.5-1.5
Differentiation	Low/intermediate/high grade	1/13/13
Microvascular invasion	N/Y	17/10
pTNM (7th)	T1/T2/T3a/T3b/T4	4/16/5/1/1
pTNM (Yao)	T1/T2/T3a/T3b/T4a/T4b	0/8/5/1/12/1

Table 2 Univariate comparison of prognostic factors

	Recurrence free survival		Global survival
	HR	P value	HR	P value
TSUVmax/LSUVmax > 1.15	14.4	0.01	5.62	0.04
TSUVmean/LSUVmean > 1.15	14.4	0.01	5.62	0.04
Pretransplant treatment	1.01	0.99	0.32	0.30
AFP	0.99	0.47	1.00	0.52
Milan	3.97	0.21	1.97	0.43
Portal vein thrombosis	5.56	0.06	0.13	0.14
TNM (7th)	1.93	0.36	1.93	0.30
Differentiation
Low grade	20.3	0.05	12.4	0.08
Intermediate grade	2.37	0.46	2.78	0.37
High grade	1.00
Number of nodules	> 107	0.99	> 107	0.99
Size of the largest nodule	1.29	0.05	1.33	0.009
Microvascular invasion	3.32	0.19	1.88	0.44
OKUDA	1.54	0.51	2.92	0.09
CLIP	1.26	0.60	2.39	0.03

AFP: Alphafoetoprotein; CLIP: Cancer of the liver italian program.