Cross-modality PET/CT and contrast-enhanced CT imaging for pancreatic cancer

Table 1 Patients characteristics n (%)

Characteristics
Sex
Male	45 (64.3 )
Female	25 (35.7 )
Median age	57 (13-81)
Final diagnosis
Malignancy	50 (71.4)
Duct adenocarcinoma	37
Cystadenocarcinoma	4
Adenosquamous Carcinoma	3
Metastatic tumor	1
Lymphoma	2
Neuroendocrine carcinoma	3
Benign	20 (28.6)
Chronic pancreatitis	8
Tubercle	1
Autoimmune pancreatitis	2
Cystadenoma/IPMN	7
Neuroendocrine neoplasm	2

IPMN: Intraductal papillary mucinous neoplasm.

Table 2 Performances of contrast-enhanced computed tomography, positron emission tomography/computed tomography, and positron emission tomography/contrast-enhanced computed tomography fusion images in diagnosing malignant pancreatic tumors

	SEN	SPE	PPV	NPV	ACC	Kappa
CECT	82.0%	65.0%	85.4%	59.1%	77.1%	0.456
PET/CT	92.0%	65.0%	86.8%	76.5%	84.2%	0.597
PET/CECT	96.0%	90.0%	96.0%	90.0%	94.3%	0.860
PET/CT vs CECT	χ2 = 2.210	χ2 = 0.000	χ2 = 0.04	χ2 = 1.303	χ2 = 1.147
	P = 0.137	P = 1.000	P = 1.303	P = 0.254	P = 0.284
PET/CECT vs PET/CT	χ2 = 0.709	χ2 = 3.584	χ2 = 2.735	χ2 = 1.238	χ2 = 3.659
	P = 0.400	P = 0.058	P = 0.098	P = 0.266	P = 0.056
PET/CECT vs CECT	χ2 = 5.005	χ2 = 3.584	χ2 = 3.289	χ2 = 5.177	χ2 = 8.400
	P = 0.025	P = 0.580	P = 0.070	P = 0.023*	P = 0.004

PET/CECT: PET/CECT fusion imagine; SEN: Sensibility; SPE: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; ACC: Accuracy.

Table 3 Performances of contrast-enhanced computed tomography, positron emission tomography/computed tomography, and positron emission tomography/contrast-enhanced computed tomography fusion images in the stage assessments of pancreatic cancer n (%)

	Peripancreatic vessel invasion					Regional lymph node metastasis					Distant metastasis
	SEN	SPE	PPV	NPV	ACC	SEN	SPE	PPV	NPV	ACC	SEN	SPE	PPV	NPV	ACC
CECT	14 (93.3)	15 (93.8)	14 (93.3)	15 (93.8)	29 (93.5)	12 (63.2)	11 (91.7)	12 (92.3)	11 (61.1)	23 (74.2)	10 (58.8)	33 (100)	10 (100)	33 (82.5)	43 (86.0)
Routine PET/CT	4 (26.7)	12 (75.0)	4 (50)	12 (52.2)	16 (51.6)	15 (78.9)	10 (83.3)	15 (88.2)	10 (71.4)	25 (80.6)	14 (82.4)	30 (90.9)	14 (82.4)	30 (90.9)	44 (88)
PET/CECT	14 (93.3)	15 (93.8)	14 (93.3)	15 (93.8)	29 (93.5)	17 (89.5)	11 (91.7)	17 (94.4)	11 (84.6)	28 (90.3)	16 (94.1)	32 (97.0)	16 (94.1)	32 (97.0)	48 (96.0)
PET/CECT vs PET/CT	χ2 = 13.889 P = 0.001	χ2 = 2.133 P = 0.144	χ2 = 5.759 P = 0.016	χ2 = 7.657 P = 0.006	χ2 = 13.697 P = 0.001	χ2 = 0.792 P = 0.374	χ2 = 0.381 P = 0.537	χ2 = 0.430 P = 0.512	χ2 = 0.678 P = 0.410	χ2 = 1.170 P = 0.279	χ2 = 1.133 P = 0.287	χ2 = 1.065 P = 0.302	χ2 = 1.133 P = 0.287	χ2 = 1.065 P = 0.302	χ2 = 2.174 P = 0.140
PET/CECT vs CECT	χ2 = 0.000 P = 1.000	χ2 = 0.000 P = 1.000	χ2 = 0.000 P = 1.000	χ2 = 0.000 P = 1.000	χ2 = 0.000 P = 1.000	χ2 = 3.640 P = 0.056	χ2 = 0.000 P = 1.000	χ2 = 0.057 P = 0.811	χ2 = 2.024 P = 0.155	χ2 = 2.763 P = 0.096	χ2 = 5.885 P = 0.015	χ2 = 1.015 P = 0.314	χ2 = 0.611 P = 0.434	χ2 = 3.880 P = 0.049	χ2 = 3.053 P = 0.081

PET/CT: Positron emission tomography/computed tomography; CECT: Contrast-enhanced CT; SEN: Sensibility; SPE: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; ACC: Accuracy.