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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2014; 20(48): 18404-18412
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18404
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18404
Table 1 Clinicopathologic characteristics and AT-rich interactive domain 1A expression in 209 patient samples of colorectal cancer n (%)
Characteristics | Value |
Gender | |
Male | 176 (84.2) |
Female | 33 (15.8) |
Age (yr) | |
Median | 55 |
Range | 19-88 |
Tumor location | |
Colon | 111 (53.1) |
Rectal | 98 (46.9) |
TNM stage (AJCC) | |
I | 35 (16.7) |
II | 48 (23.0) |
III | 55 (26.3) |
IV | 71 (34.0) |
T stage | |
T1 | 10 (4.8) |
T2 | 35 (16.7) |
T3 | 53 (25.4) |
T4 | 111 (53.1) |
N stage | |
N0 | 98 (46.9) |
N1 | 56 (26.8) |
N2 | 55 (26.3) |
M stage | |
M0 | 138 (66.0) |
M1 | 71 (34.0) |
Pathologic differentiation | |
Poor | 36 (17.2) |
Moderate | 148 (70.8) |
Well | 25 (12.0) |
Tumor size (cm) | |
≤ 5 | 136 (65.1) |
> 5 | 73 (34.9) |
Expression of ARID1a | |
Negative | 54 (25.8) |
Positive | 155 (74.2) |
Table 2 Correlation between AT-rich interactive domain 1A expression and clinicopathologic characteristics of colorectal cancer patients n (%)
Characteristics | ARID1a | P value | |
Negative | Positive | ||
Gender | 0.132 | ||
Male | 42 (77.8) | 134 (86.5) | |
Female | 12 (22.2) | 21 (13.5) | |
Age (yr) | 0.409 | ||
≤ 55 | 30 (55.6) | 76 (49.0) | |
> 55 | 24 (44.4) | 79 (51.0) | |
Tumor location | 0.293 | ||
Colon | 32 (59.3) | 79 (51.0) | |
Rectal | 22 (40.7) | 76 (49.0) | |
TNM stage (AJCC) | 0.020 | ||
I | 4 (7.4) | 31 (20.0) | |
II | 13 (24.1) | 35 (22.6) | |
III | 12 (22.2) | 43 (27.7) | |
IV | 25 (46.3) | 46 (29.7) | |
T stage | 0.771 | ||
T1 | 1 (1.9) | 9 (5.8) | |
T2 | 6 (11.1) | 29 (18.7) | |
T3 | 20 (37.0) | 33 (21.3) | |
T4 | 27 (50.0) | 84 (54.2) | |
N stage | 0.638 | ||
N0 | 23 (42.6) | 75 (48.4) | |
N1 | 17 (31.5) | 39 (25.1) | |
N2 | 14 (25.9) | 41 (26.5) | |
M stage | 0.026 | ||
M0 | 29 (53.7) | 109 (70.3) | |
M1 | 25 (46.3) | 46 (29.7) | |
Pathologic differentiation | 0.035 | ||
Poor | 14 (25.9) | 22 (14.2) | |
Moderate | 36 (66.7) | 112 (72.3) | |
Well | 4 (7.4) | 21 (13.5) | |
Tumor size (cm) | 0.170 | ||
≤ 5 | 31 (57.4) | 105 (67.7) | |
> 5 | 23 (42.6) | 50 (32.3) |
Table 3 Univariate and multivariate analyses of various prognostic parameters in stage IV patients with colorectal cancer using Cox-regression analysis n (%)
Characteristics | Univariate analysis | Multivariate analysis | |||
P value | HR | 95%CI | P value | ||
Gender | 0.258 | ||||
Male | 40 (56.3) | ||||
Female | 31 (43.7) | ||||
Age (yr) | 0.934 | ||||
≤ 55 | 39 (54.9) | ||||
> 55 | 32 (45.1) | ||||
ARID1a expression | 0.027 | 2.49 | 1.13-5.51 | 0.024 | |
Negative | 25 (35.2) | ||||
Positive | 46 (64.8) | ||||
T stage | 0.038 | 2.01 | 1.08-3.75 | 0.029 | |
T1 | 1 (1.4) | ||||
T2 | 5 (7.0) | ||||
T3 | 43 (60.6) | ||||
T4 | 22 (31.0) | ||||
N stage | 0.929 | ||||
N0 | 12 (16.9) | ||||
N1 | 27 (38.0) | ||||
N2 | 32 (45.1) | ||||
Pathologic differentiation | 0.458 | ||||
Poor | 17 (23.9) | ||||
Moderate | 51 (71.8) | ||||
Well | 3 (4.3) | ||||
Tumor size (cm) | 0.261 | ||||
≤ 5 | 43 (60.6) | ||||
> 5 | 28 (39.4) | ||||
Metastatic site | 0.806 | ||||
Single | 52 (73.2) | ||||
Multiple | 19 (26.8) | ||||
Metastasis limited to the liver | 0.519 | ||||
No | 37 (52.1) | ||||
Yes | 34 (47.9) | ||||
Resection of metastatic tumors1 | 0.002 | 0.33 | 0.16-0.67 | 0.002 | |
No | 21 (29.6) | ||||
Yes | 50 (70.4) |
- Citation: Wei XL, Wang DS, Xi SY, Wu WJ, Chen DL, Zeng ZL, Wang RY, Huang YX, Jin Y, Wang F, Qiu MZ, Luo HY, Zhang DS, Xu RH. Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer. World J Gastroenterol 2014; 20(48): 18404-18412
- URL: https://www.wjgnet.com/1007-9327/full/v20/i48/18404.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i48.18404