Retrospective Cohort Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2014; 20(48): 18367-18374
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18367
Table 1 Baseline characteristics of analyzed patients n (%)
PatientsValue
Total183
Gender
Male93 (51)
Female90 (49)
Extent of disease
Pancolitis112 (61)
Left-side colitis40 (22)
Proctitis31 (17)
Median (IQR) age at onset32 (22-45)
Median (range) duration of disease, mo108 (54-202)
Median (range) age of undergoing colonoscopy44 (33-59)
Concomitant medications
Aminosalicylate163 (89)
Corticosteroids23 (13)
Mercaptopurine/azathioprine70 (38)
Tacrolimus5 (3)
Biologics7 (4)
Colonoscopy findings (maximum index in the colorectum)
MES 080 (44)
MES 189 (48)
MES 214 (8)
Table 2 Characteristics of patients with Mayo endoscopic subscore 0 vs 1 or 2 n (%)
CharacteristicsMES 0 (n = 80)MES 1, 2 (n = 103)P value
Gender
Male45 (56)48 (47)0.2
Female35 (44)55 (53)
Median age, yr (IQR)49 (37-62)40 (32-54)0.009
Median duration of disease, mo (IQR)98 (52-213)122 (57-202)0.73
Median age at onset, yr (IQR)36 (25-50)29 (19-40)0.009
Extent of disease
Pancolitis42 (53)70 (68)0.1
Left-side colitis21 (26)19 (18)
Proctitis17 (21)14 (14)
Concomitant medications
Aminosalicylate72 (90)91 (88)0.72
Corticosteroids12 (15)11 (11)0.38
Mercaptopurine/azathioprine28 (35)42 (41)0.43
Tacrolimus3 (4)2 (2)0.46
Biologics2 (3)5 (5)0.41
Blood markers, median (IQR)
CRP (mg/L)0.4 (0.2-1.0)0.5 (0.2-1.2)0.3
WBC (/μL)5160 (4130-5990)5660 (4830-6800)0.017
Hb (g/dL)13.6 (12.4-15.0)13.5 (12.4-14.7)0.75
PLT (× 104/μL)24.7 (21.7-27.6)29.1 (25.6-33.4)< 0.0001
Alb (g/dL)4.5 (4.2-4.8)4.4 (4.1-4.7)0.17
Table 3 Univariate and multivariate analysis for factors predictive of Mayo endoscopic subscore 0
ORUnivariate analysis95%CIP valueORMultivariate analysis95%CIP value
Age > 48 yr2.591.42-4.780.0021.880.79-4.520.15
Age at onset > 32 yr2.391.32-4.380.0041.460.61-3.460.39
WBC < 5900/μL2.651.43-5.050.0022.371.19-4.810.014
PLT < 26 × 104/μL4.742.55-9.01< 0.00014.102.15-7.99< 0.0001
Table 4 Predictive values of white blood cell and platelet count for Mayo endoscopic subscore 0 in patients with sustained clinical remission
WBC < 5900/μLonlyPLT < 26 × 104/μLonlyEither WBC < 5900/μL or PLT < 26 × 104/μLBoth WBC < 5900/μL and PLT < 26 × 104/μL
Sensitivity (95%CI)0.74 (0.66-0.81)0.65 (0.57-0.72)0.91 (0.85-0.95)0.48 (0.40-0.54)
Specificity (95%CI)0.49 (0.42-0.54)0.72 (0.66-0.77)0.39 (0.34-0.42)0.82 (0.76-0.87)
Table 5 Change in blood marker values in patients with or without maintenance of complete mucosal healing n (%)
VariablesMaintenance of MES 0 (n = 26)Shift to MES 1 (n = 21)P value
Extent of disease
Pancolitis13 (50)13 (62)
Left-side colitis10 (38)3 (14)
Proctitis3 (12)5 (24)0.15
Median (IQR) age at onset36 (27-49)28 (23-43)0.2
Median (range) duration of disease, mo132 (55-220)152 (64-244)0.65
Change in values of parameters
median (IQR)
ΔCRP (mg/L)0.1 (-0.1-0.4)0 (0.2-0.4)0.95
ΔWBC (/μL)-200 (-1680-780)280 (-330-1030)0.16
ΔHb (g/dL)0.1 (-0.3-0.8)0.4 (-0.1-0.8)0.25
ΔPLT (× 104/μL)-0.6 (-2.4-1.5)3.8 (1.5-8.0)< 0.0001
ΔAlb (g/dL)0.1 (-0.2-0.3)0 (-0.1-0.2)0.82