Impact of the gut microbiota on rodent models of human disease

Table 1 Examples of rodent models in which germ free status has a documented impact

Model	Disease
Models with increased disease incidence or severity
β-lactoglobulin induced mouse[51]	Allergy
NOD mouse[42]	Type 1 diabetes
MyD88 KO NOD mouse[42]	Type 1 diabetes
Restrained mouse[43]	Stress
Models with decreased disease incidence or severity
Ovalbumin-specific TCR TG mouse[44]	Allergy
Swiss-Webster mouse[45]	Anxiety
Collagen induced rat[52]	Arthritis
HLA-B27 TG rat[53]	IBD
IL-2 KO mouse[54,55]	IBD
IL-10 KO mouse[56]	IBD
TCRα KO mouse[57]	IBD
Dextran sulfate sodium induced mouse[46]	IBD
SAMP1/Yit mouse[47]	IBD
Adoptive T-cell transfer in the mouse[48]	IBD
Carrageenan, LPS, or formalin induced mouse[49]	Inflammatory pain
C57BL/6 mouse[65]	Obesity
C57BL/6 mouse[65]	Type 2 diabetes

NOD: Non-obese diabetic; MyD88: Myeloid differentiation primary response gene 88; KO: Knockout; TCR: T cell receptor; TG: Transgenic; HLA-B27: Human leucocyte antigen subtype B27; IL-2: Interleukin 2; SAMP1/Yit: Senescence accelerated mice prone line 1 Yakult; LPS: Lipopolysaccharide. IBD: Inflammatory bowel disease.