Anterior vs conventional approach hepatectomy for large liver cancer: A meta-analysis

Table 1 Quality assessment of the included randomized controlled trials based on the Jadad scoring system

Ref.	Randomized	Appropriately randomized	Appropriately double blinded	Description of withdrawals	Jadad score	Study quality
Liu et al[7]	Yes	Yes	No	Yes	4	High
Capussotti et al[16]	Yes	Yes	No	Yes	4	High

Table 2 Quality assessment of the included non-randomized controlled trials based on the Newcastle-Ottawa scale

Ref.	Selection stars	Comparability stars	Outcome stars	Total stars	Study quality
Lai et al[1]	2	2	2	6	High
Liu et al[3]	2	2	3	7	High
Takács et al[14]	1	2	2	5	High
Wang et al[15]	2	2	3	7	High
Wu et al[13]	2	2	3	7	High
Li et al[12]	3	2	2	7	High

Table 3 Characteristics of the included trials

Ref.	Design	Country	Patients, n (AAH/CAH)	Disease	Tumor size, cm (AAH/CAH)	Tumor≥5 cm
Lai et al[1]	CCT	China (Hong Kong)	25/34	HCC	12.8/8.4	85%
Liu et al[3]	CCT	China (Hong Kong)	54/106	HCC	10.3/10.5	100%
Liu et al[7]	RCT	China (Hong Kong)	60/60	HCC	10.5/10.0	100%
Takács et al[14]	CCT	Hungary	52/67	HCC or MHC	11.6/10.0	NR
Wang et al[15]	CCT	China (Taiwan)	14/11	HCC	12.5/12.0	100%
Wu et al[13]	CCT	China (Taiwan)	33/38	HCC	12.0/9.7	100%
Li et al[12]	CCT	China	92/96	HCC	12.2/10.4	100%
Capussotti et al[16]	RCT	Italy	33/32	HCC or MHC	6.0/5.2	NR

All values are means. AAH: Anterior approach hepatectomy; CAH: Conventional approach hepatectomy; CCT: Controlled clinical trial; HCC: Hepatocellular carcinoma; MHC: Metastatic hepatic carcinoma; NR: Not reported; RCT: Randomized controlled trial.

Table 4 Characteristics of patients in included studies

Ref.	AAH/CAH
	Mean blood loss(L)	Transfusion requirements(n:total)	Hospital stay(d)	Mortality,n (%)	Recurrence,n (%)	Complication,n (%)	Tumor rupture(n:total)
Lai et al[1]	3.2 (2.0-4.4)/3.1 (2.0-4.2)1	NR	NR	1 (4)/2 (5.9)	NR	21 (84)/13 (38.2)	3:25/1:34
Liu et al[3]	2.0 (0.6-2.0)/2.5 (0.2-2.0)1	31:54/86:106	NR	0 (0)/14 (13.2)	NR	25 (46.3)/56 (52.8)	1:54/7:106
Liu et al[7]	0.8 (0.5-1.4)/1.0 (0.5-2.2)2	4:60/17:60	11 (7.3-15)/12.5 (8-19)2	1 (1.7)/6 (0.28)	33 (55.9)/30 (55.6)	16 (26.7)/20 (33.3)	1:60/1:60
Takács et al[14]	NR	30:52/49:67	20.4 ± 13.5/18.3 ± 6.9	0 (0)/2 (3.0)	NR	20 (38.5)/24 (35.8)	NR
Wang et al[15]	0.4 (0.2-0.9)/1.0 (0.5-1.2)2	3:14/8:11	15 (10.7-19.7)/16 (13-19)2	0 (0)/0 (0)	NR	9 (64.3)/8 (72.7)	NR
Wu et al[13]	0.5 (0.3-0.7)/0.6 (0.3-1.0)1	4:33/18:38	10 (8.0-19.5)/11 (8.0-14.0)1	2 (6.1)/5 (13.2)	12 (38.7)/27 (81.8)	8 (24.2)/16 (42.1)	4:33/4:38
Li et al[12]	1.2 ± 1.1/2.1 ± 2.03	38:92/54:96	23 ± 11/24 ± 103	2 (2.2) /3 (3.1)	40 (47.6)/50 (60.2)	13 (14.1)/17 (17.7)	NR
Capussotti et al[16]	0.4 ± 0.66/0.5 ± 0.533	6:33/3:32	10.0 ± 6.59/11.5 ± 13.63	1 (3.0)/1 (3.1)	NR	17 (51.5)/18 (56.3)	0:33/0:32
Total	-	116:338/ 235:410	-	7 (1.9)/33 (7.4)	85 (48.9)/107 (63.0)	129 (35.5)/172 (38.7)	9:205/ 13:270

¹Values are means (95%CI), P < 0.05;

²Values are median (interquartile range);

³Values are mean ± SD. AAH: Anterior approach hepatectomy; CAH: Conventional approach hepatectomy; NR: Not reported.