Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer

Table 1 Performance of tumor necrosis factor receptor-associated protein 1 staining in distinguishing progressors from non-progressors

Using TRAP1 expression in different histologic grades as a biomarker (n)	Controls (n)	AUC value	Sensitivity at
			90% specificity	80% specificity
LGD (29)	Non-progressors (38)	0.86	69%	79%
HGD (14)	Non-progressors (38)	0.97	86%	100%
Cancer (17)	Non-progressors (38)	0.87	82%	88%
Progressor rectal tissue (39)	Non-progressors (38)	0.71	41%	59%
Highest TRAP1 in dysplasia (36)	Non-progressors (38)	0.94	86%	94%
Highest overall TRAP1 (42)	Non-progressors (38)	0.88	76%	83%

LGD: Low grade dysplasia; HGD: High grade dysplasia; TRAP1: Tumor necrosis factor receptor-associated protein 1.

Table 2 Expression pattern of tumor necrosis factor receptor-associated protein 1 among different histologic grades within each progressor

Progressor case	Highest histologic grade present in the progressor	Rectum	LGD	HGD	CA
1	LGD	-	-	NA	NA
2	LGD	-	-	NA	NA
3	LGD	-	-	NA	NA
4	LGD	-	-	NA	NA
5	LGD	+	+	NA	NA
6	LGD	-	-	NA	NA
7	LGD	+	+	NA	NA
8	LGD	-	-	NA	NA
9	LGD	-	-	NA	NA
10	LGD	+	+	NA	NA
11	LGD	+	+	NA	NA
12	LGD	-	-	NA	NA
13	LGD	+	+	NA	NA
14	LGD	-	-	NA	NA
15	LGD	-	-	NA	NA
16	LGD	-	-	NA	NA
17	LGD	+	+	NA	NA
18	LGD	+	+	NA	NA
19	LGD	+	+	NA	NA
20	HGD	+	+	NA	NA
21	HGD	-	-	NA	NA
22	HGD	+	+	+	NA
23	HGD	+	+	+	NA
24	HGD	+	+	+	NA
25	CA	-	-	+	+
26	CA	+	+	+	+
27	CA	+	+	+	+
28	CA	NA	NA	NA	+
29	CA	-	-	+	-
30	CA	+	+	+	+
31	CA	+	+	+	NA
32	CA	-	-	NA	-
33	CA	+	+	NA	+
34	CA	NA	NA	+	+
35	CA	NA	NA	NA	+
36	CA	+	+	+	+
37	CA	+	+	+	+
38	CA	+	+	NA	+
39	CA	+	+	+	+
40	CA	+	+	NA	+
41	CA	+	+	+	+
42	CA	+	+	NA	+

"+": Positive tumor necrosis factor receptor-associated protein 1 (TRAP1) staining; "-": Negative TRAP1 staining; NA: Not available; LGD: Low grade dysplasia; HGD: High grade dysplasia; CA: Cancer.