Colon capsule endoscopy: What we know and what we would like to know

Table 1 Regimen of preparation[10,29]

Schedule		Intake
Day -2	Bedtime	Senna, 4 tb (48 mg)
Day -1	All Day	Clear Liquid Diet
	Evening (7-9 pm)	2 L PEG
Exam Day	7-9 am	2 L PEG
	10:00 AM	Capsule Ingestion1
	(about 1 h after last intake of PEG)
	after small bowel detection	1st Boost
		40 mL NaP + 1 L water with Gastrografin3
		(50 mL)
	3 h after 1st Boost	2nd Boost
		20 mL NaP + 0.5 L water with Gastrografin3 (25 mL)2
	2 h after 2nd Boost	Suppository
		10 mg Bisacodyl2

¹Ten mg Metoclopramide tablet if capsule delayed in stomach > 1 h;

²Only if capsule not excreted yet;

³Sodium-amidotrizoate and meglumine-amidotrizoate.

Table 2 Accuracy of colon capsule endoscopy 2 for polyp detection

Ref.	Pts	Adequatecleansing	Excretionrate	Polyp≥6 mm		Polyp≥10 mm
				Sensitivity(95%CI)	Specificity(95%CI)	Sensitivity(95%CI)	Specificity(95%CI)
Eliakim et al[9]	104	78%	81%1	89%	76%	88%	89%
		(68%-86%)		(70%-97%)	(72%-78%)	(56%-98%)	(86%-90%)
Spada et al[12]	117	85%	81%1	84%	64%	88%	95%
		(73%-88%)		(74%-95%)	(52%-76%)	(76%-99%)	(90%-100%)
Rex et al[19]	884	80%	91%2	88%	82%	92%	95%
		(76%-83%)		(82%-93%)	(80%-83%)	(82%-97%)	(94%-95%)

¹Within 8 h;

²10 h post ingestion.

Table 3 Results of colon capsule endoscopy in incomplete conventional colonoscopy

Ref.	No.	Completeness(%)	CCE complementary findings (%)
Pioche et al[24]	107	83	34
Alarcón-Fernández et al[25]	34	85	23.5
Triantafyllou et al[26]	75	90.7	44
Nogales et al[27]	96	93	4512
Baltes et al[28]	74	95	49/2812
Spada et al[29]	100	98	241

¹Significant polyps;

²Cancers. CCE: Colon capsule endoscopy.

Table 4 Colon capsule endoscopy accuracy for ulcerative colitis

Ref.	n	Type of CCE	Sensitivity	Specificity	PPV	NPV
Sung et al[34]	100	CCE1	89 (80-95)	75 (51-90)	93 (84-97)	65 (43-83)
Oliva et al[38]	29	CCE2	96 (79-99)	100 (61-100)	100 (85-100)	85 (49-97)

CCE: Colon capsule endoscopy.