Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Table 1 Baseline characteristics and status of ulcer at 4 wk after endoscopic submucosal dissection

Parameter	2 wk(n = 27)	4 wk(n = 33)	P value
Clinical background
Age (yr)	73.3 ± 7.8	70.8 ± 9.3	NS2
Gender (male/female)	17/10	19/14	NS3
Helicobacter pylori infection (+/-/unknown)	18/8/1	25/6/2	NS3
Location (upper/middle/lower)	3/10/14	1/14/18	NS3
Size of ESD (mm2)	777.6 ± 437.8	1251.2 ± 918.6	0.0484
Serum albumin (g/dL)	4.1 ± 0.4	4.1 ± 0.4	NS2
Comorbidity
Diabetes (+/-)	3/24	6/27	NS3
Hyperlipidemia (+/-)	7/20	8/25	NS3
Hypertension (+/-)	8/19	11/22	NS3
Status of ulcer at 4 wk after ESD1
Stage of ulcer (active/healing/scar)	0/20/6	0/28/5	NS2
	Ulcer healing rate (%) (average, 95%CI)	96.1 (94.6-97.5)	94.8 (92.6-97.1)	NS3

¹One patient in 2 wk group who showed bleeding within 2 wk and received endoscopic treatment and proton pump inhibitor for 4 wk was excluded for these analysis;

²Paired t-test;

³χ² test;

⁴Mann-Whitney U test. ESD: Endoscopic submucosal dissection; NS: No significance.

Table 2 Clinical characteristics of artificial ulcer after endoscopic submucosal dissection treatment with rapid healing

Parameter	Healing area in healing stage		P value
	≥ 968.5 mm2 (n = 24)	< 968.5 mm2 (n = 24)
Age (yr)	72.6 ± 8.9	68.8 ± 9.0	NS1
Sex (male/female)	15/9	15/9	NS2
Location of tumors (upper/middle/lower third)	1/11/12	1/8/15	NS2
Helicobacter pylori infection (+/-/unknown)	17/5/2	16/8/0	NS2
Initial ulcer size (mm2)	1689.3 ± 835.7	633.5 ± 243.8	< 0.0013
Healing rate (%)	94.6 ± 4.5	94.0 ± 6.6	NS3
Treatment period (2 wk/4 wk)	7/17	13/11	NS2
Comorbidity
Diabetes (yes/no)	4/20	5/19	NS2
Hyperlipidemia (yes/no)	3/21	7/17	NS2
Hypertension (yes/no)	10/14	3/21	0.0492

¹Paired t-test;

²χ² test;

³Mann-Whitney U test. NS: No significance.

Table 3 Analysis for status of ulcer and healing area in healing stage after adjusting the size of endoscopic submucosal dissection

	2 wk(n = 17)	4 wk(n = 23)	P value
Size of ESD (mm2)	962.2 ± 390.8	1016.2 ± 397.3	NS1
Ulcer healing rate (%) (average, 95%CI)	94.5 (92.7-96.3)	94.0 (91.1-96.9)	NS1
Ulcer healing speed in (mm2/mo)	908.8 ± 370.6	960.7 ± 377.7	NS1

¹Paired t-test; ESD: Endoscopic submucosal dissection; NS: No significance; CI: Confidence interval.