Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

Table 1 Correlation between immunohistochemistry insulin-like growth factor receptor-1 expression on pre-radiation biopsy specimens and clinico-pathological parameters

Clinico-pathological parameters	Cases	IGF-1R		P value
		0-+	++-+++
Age
< 55	43	14	29
≥ 55	44	19	25	0.424
Gender
Male	49	18	31
Female	38	15	23	0.969
Stage
I-II	47	24	23
III	40	9	31	0.012a
Differentiation
Well, moderately	51	21	30
Poorly	36	12	24	0.604
Size (cm)
< 4	46	19	27
≥ 4	41	14	27	0.642

^aP < 0.05 vs stages I-II. IGF-1R: Insulin-like growth factor receptor-1.

Table 2 Relationship between insulin-like growth factor receptor-1 expression on pre-radiation biopsy specimens and tumor radiosensitivity in rectal carcinoma

IGF-1R expression	Cases	RCRG			P value	r
		1	2	3
IHC
0-+	33	18	9	6
++-+++	54	13	19	22	< 0.001	0.401
RT-PCR
-	10	8	2	0
+	77	23	26	28	< 0.001	0.497

RCRG: Rectal Cancer Regression Grades; IHC: Immunohistochemistry; RT-PCR: Reverse transcription-polymerase chain reaction; IGF-1R: Insulin-like growth factor receptor-1.