New treatments for chronic hepatitis C: An overview for paediatricians

Table 1 End-points generally evaluated to assess treatment efficacy

RVR	Undetectable serum hepatitis C virus (HCV) RNA after 4 wk of treatment
EVR	Undetectable or at least a 2 log decrease in serum HCV RNA from baseline level after 12 wk of treatment
End-of-treatment response	Undetectable serum HCV RNA at the conclusion of treatment
SVR	Undetectable serum HCV RNA 24 wk after the end of treatment
Non-response	Detectable serum HCV RNA at 24 wk of treatment without any significant decrease in serum HCV RNA level
Relapse	Detection of serum HCV RNA after SVR had been achieved

RVR: Rapid virological response; EVR: Early virological response; SVR: Sustained virological response.