Autoimmune gastritis presenting as iron deficiency anemia in childhood

Table 1 Demographic, clinical and laboratorial characterization of autoimmune gastritis patients

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Mean ± SD
Patient Data
Age (yr)	14.75	16	14.1	16.1	7.25	13.6 ± 2.87
Gender	M	F	M	F	F	-
Ethnicity	African	African	Caucasian	Caucasian	Caucasian	-
Personal History	-	-	Type I Diabetes	-	-	-
Familial History	Mother (sarcoidosis, multiple myeloma)	Mother (breast cancer). Uncles (type I diabetes)	Mother (breast cancer)	Mother (autoimmune thyroiditis)	Mother (autoimmune thyroiditis)	-
Symptoms	Dyspepsia	Dyspepsia	-	-	-	-
Laboratorial Data
Hemoglobin (g/dL)	9.1	10.7	9.7	9.9	8.5	9.56 ± 0.71
Serum ferritin (ng/mL)	4.5	5.6	4.1	2.9	3.,2	4.06 ± 0.96
(Ref: 7-140)
Vitamin B12 (pg/mL)	-	509	236	618	-	454 ± 160
(Ref: 200-835)
Gastrin (pg/mL)	106	479	548	32	800	393 ± 286
(Ref: < 100)
PGI/ PGII	1.68	0.9	2.07	1.09	1.04	1.36 ± 0.46
(Ref: > 1.0)
PCA	(+)	(+)	(+)	(+)	(+)	-
IFA	(-)	(-)	(-)	(-)	(-)	-
TPO/Tg-Ab	(-)	(-)	(-)	(+)	(-)	-

PCA: Parietal-cell antibody; IFA: Intrinsic factor antibody; TPO/Tg-Ab: Anti-thyroid antibodies.

Table 2 Gastric biopsies immunostaining counts for T lymphocytes, B lymphocytes, and macrophages

	CD3		CD20		CD68
	Patients1	Control2	Patients	Control	Patients	Control
	(range)		(range)		(range)
L. propria	204.4	66	40.6	8
	(108-284)	-	(16-73)
Epithelium	77.6	6	0	0
	(16-143)
Crypts	170.2	17	0	0
	(77-355)
Overall	-	-	-	-	50.8	9
					(16-119)

¹Patients: Results expressed as mean number (and range) of stained cells per power field (× 40);

²Control: Histologically normal corpus biopsy.