Jeong JY, Kim TY, Sohn JH, Kim Y, Jeong WK, Oh YH, Yoo KS. Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers. World J Gastroenterol 2014; 20(38): 13920-13929 [PMID: 25320528 DOI: 10.3748/wjg.v20.i38.13920]
Corresponding Author of This Article
Joo Hyun Sohn, MD, PhD, Department of Internal Medicine, Hanyang Univesity Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, South Korea. sonjh@hanyang.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 4 Comparison of diagnostic performance between noninvasive serum marker for discriminating F0-1 vs F2-4 (significant fibrosis), F0-2 vs F3-4 (advanced fibrosis) and F0-3 vs F4 (cirrhosis) (n =61)
AUROC
95%CI
Pairwise comparison of ROC curves
Factor
Difference between areas (95%CI)
P value
Significant fibrosis
SWE
0.908
0.806-0.967
HA
0.097 (-0.012-0.205)
0.081
Type IV
0.067 (-0.003-0.167)
0.189
APRI
0.217 (0.074-0.359)
0.003
HA
0.812
0.691-0.900
Type IV
0.030 (-0.092-0.152)
0.634
APRI
0.120 (-0.041-0.281)
0.145
Type IV
0.841
0.725-0.922
APRI
0.150 (-0.006-0.305)
0.059
APRI
0.691
0.560-0.803
Advanced fibrosis
SWE
0.893
0.787-0.957
HA
0.004 (-0.093-0.101)
0.939
Type IV
0.017 (-0.080-0.113)
0.735
APRI
0.150 (0.013-0.287)
0.032
HA
0.897
0.792-0.960
Type IV
0.020 (-0.074-0.115)
0.671
APRI
0.154 (0.014-0.293)
0.031
Type IV
0.876
0.767-0.947
APRI
0.133 (-0.010-0.277)
0.069
APRI
0.743
0.615-0.846
Cirrhosis
SWE
0.877
0.768-0.947
HA
0.002 (-0.114-0.118)
0.974
Type IV
0.027 (-0.084-0.138)
0.631
APRI
0.194 (0.031-0.358)
0.002
HA
0.879
0.770-0.948
Type IV
0.029 (-0.072-0.130)
0.571
APRI
0.196 (0.022-0.371)
0.027
Type IV
0.850
0.736-0.928
APRI
0.167 (-0.003-0.338)
0.055
APRI
0.683
0.551-0.796
Table 5 Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) in patients with chronic viral hepatitis (n =36)
AUROC
95%CI
Pairwise comparison of ROC curves
Factor
Difference between areas (95%CI)
P value
Significant fibrosis
SWE
0.935
0.800-0.989
HA
0.277 (0.070-0.485)
0.009
Type IV
0.158 (-0.009-0.325)
0.063
APRI
0.077 (-0.066-0.220)
0.289
HA
0.658
0.482-0.807
Type IV
0.119 (-0.084-0.326)
0.257
APRI
0.200 (-0.029-0.429)
0.086
Type IV
0.777
0.608-0.898
APRI
0.081 (-0.126-0.288)
0.445
APRI
0.858
0.701-0.951
Advanced fibrosis
SWE
0.914
0.771-0.980
HA
0.094 (-0.054-0.243)
0.214
Type IV
0.120 (-0.030-0.271)
0.118
APRI
0.086 (-0.061-0.234)
0.250
HA
0.819
0.656-0.927
Type IV
0.026 (-0.120-0.172)
0.725
APRI
0.008 (-0.168-0.183)
0.931
Type IV
0.793
0.626-0.909
APRI
0.034 (-0.153-0.221)
0.722
APRI
0.827
0.665-0.932
Table 6 Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) with non-viral chronic liver diseases (n = 25)
AUROC
95%CI
Pairwise comparison of ROC curves
Factor
Difference between areas (95%CI)
P value
Significant fibrosis
SWE
0.979
0.826-0.988
HA
0.035 (-0.058-0.128)
0.465
Type IV
0.035 (-0.051-0.121)
0.429
APRI
0.389 (0.163-0.615)
0.001
HA
0.944
0.773-0.993
Type IV
0.000 (-0.103-0.103)
1.000
APRI
0.354 (0.137-0.572)
0.001
Type IV
0.944
0.773-0.993
APRI
0.354 (0.130-0.578)
0.002
APRI
0.590
0.378-0.781
Advanced fibrosis
SWE
0.910
0.726-0.985
HA
0.077 (-0.042-0.196)
0.206
Type IV
0.090 (-0.034-0.214)
0.156
APRI
0.295 (0.060-0.530)
0.014
HA
0.987
0.839-1.000
Type IV
0.013 (-0.034-0.060)
0.593
APRI
0.372 (0.155-0.589)
0.001
Type IV
1.000
0.862-1.000
APRI
0.385 (0.160-0.609)
0.001
APRI
0.615
0.401-0.801
Citation: Jeong JY, Kim TY, Sohn JH, Kim Y, Jeong WK, Oh YH, Yoo KS. Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers. World J Gastroenterol 2014; 20(38): 13920-13929