He J, Zeng ZC, Shi SM, Yang P. Clinical features, outcomes and treatment-related pneumonitis in elderly patients with esophageal carcinoma. World J Gastroenterol 2014; 20(36): 13185-13190 [PMID: 25278715 DOI: 10.3748/wjg.v20.i36.13185]
Corresponding Author of This Article
Zhao-Chong Zeng, MD, PhD, Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Handan Rd 220, Shanghai 200032, China. zeng.zhaochong@zs-hospital.sh.cn
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 28, 2014; 20(36): 13185-13190 Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13185
Table 1 Biological characteristics of tumors in elderly and non-elderly patients with esophageal carcinoma n (%)
Clinicopathological parameter
n
Non-elderly
Elderly
P
Gender
0.098
Male
180
93 (51.7)
87 (48.3)
Female
56
36 (64.3)
20 (35.7)
Tumor location
0.066
Cervical esophagus and upper thoracic portion
64
29 (43.3)
38 (56.7)
Mid-thoracic portion
49
61 (57.0)
46 (43.0)
Lower thoracic portion
39 (62.9)
23 (37.1)
Tumor type
0.000
Adenocarcinoma
31
27 (87.1)
4 (12.9)
Squamous cell carcinoma
205
102 (49.8)
103 (50.2)
Distant metastasis
0.021
M0
216
123 (56.9)
93 (43.1)
M1
20
6 (30.0)
14 (70.0)
Recurrence and metastasis after radiotherapy
0.008
Yes
143
88 (61.5)
55 (38.5)
No
93
41 (44.1)
52 (55.9)
Lymph node metastasis
0.000
N0
111
74 (66.7)
37 (33.3)
N1
125
55 (44.0)
70 (56.0)
TNM stage
0.002
I
101
68 (67.3)
33 (32.7)
II
83
37 (44.6)
46 (55.4)
III
32
18 (56.3)
14 (43.8)
IV
20
6 (30.0)
14 (70.0)
Table 2 Univariate analysis of prognostic factors
n
Survival rate (elderly)
P
n
Survival rate (non-elderly)
P
1 yr
3 yr
5 yr
1 yr
3 yr
5 yr
Gender
0.837
0.800
Male
93
66.5%
10.8%
2.2%
87
71.3%
12.7%
0.5%
Female
36
77.8%
8.3%
-
20
77.5%
5.3%
1.6%
Tumor type
0.878
0.039
Squamous
102
67.5%
11.2%
1.5%
103
74.8%
11.7%
0.3%
Non-squamous
27
75.9%
5.6%
0%
4
25.0%
-
-
Tumor location
0.360
0.212
Upper thoracic
29
72.4%
8.6%
4.3%
38
71.1%
17.5%
4.8%
Mid-thoracic
61
71.9%
12.1%
0%
46
67.4%
4.3%
-
Lower thoracic
39
62.8%
10.3%
-
23
87.0%
10.8%
-
Lymphatic metastasis
0.053
0.063
N0
74
77.0%
9.5%
1.0%
37
81.1%
18.5%
2.0%
N1
55
59.6%
9.3%
0.5%
70
68.6%
6.6%
0%
Distant metastasis
0.000
0.000
M0
123
71.4%
10.9%
1.7%
93
81.7%
12.9%
2.0%
M1
6
20.8%
-
-
14
14.3%
-
-
TNM stage
0.000
0.000
I
68
80.9%
11.8%
0.8%
33
84.8%
23.9%
5.1%
II
37
67.1%
11.2%
0.5%
46
91.3%
0.79%
-
III
18
44.0%
2.5%
0%
14
42.9%
-
-
IV
6
25.0%
-
-
14
14.3%
-
-
TRP
0.000
0.026
Yes
33
59.1%
0%
-
21
57.1%
-
-
No
96
72.8%
13.5%
2.2%
86
76.7%
13.1%
1.8%
TRP grade
0.000
0.047
II
20
81.0%
0%
-
14
64.0%
-
-
III
13
22.1%
-
-
7
42.9%
-
-
IV
0
-
-
-
0
-
-
-
Radiation dose
0.620
0.969
≤ 60 Gy
58
72.4%
10.3%
0%
54
70.4%
13.9%
0.5%
> 60 Gy
71
67.4%
10.4%
2.3%
53
75.5%
7.0%
1.5%
Table 3 Multivariate analysis of prognostic factors in the elderly and non-elderly esophageal carcinoma groups
Variable
Elderly
Non-elderly
P
HR (95%CI)
P
HR (95%CI)
Pathological type
0.433
1.201 (0.759-1.901)
0.451
0.661 (0.224-1.944)
TRP
0.268
0.359 (0.059-2.199)
0.862
1.223 (0.126-11.838)
TRP grade
0.057
2.044 (0.980-4.261)
0.640
1.254 (0.486-3.235)
Distant metastasis
0.223
1.969 (0.662-5.861)
0.025
3.166 (1.155-8.679)
TNM stage
0.024
1.348 (1.040-1.748)
0.001
1.789 (1.271-2.517)
Table 4 Multivariate Cox regression analysis of prognostic factors in patients in whom treatment-related pneumonitis occurred
B
SE
Wald
df
P
Exp(B)
95%CI for Exp(B)
Lower
Upper
TRP grade
0.465
0.315
2.182
1
0.140
1.592
0.859
2.949
Lymph node metastasis
-0.459
0.461
0.989
1
0.320
0.632
0.256
1.561
Distant metastasis
-0.113
0.923
0.015
1
0.902
0.893
0.146
5.454
Tumor TNM stage
0.592
0.296
3.983
1
0.046
1.807
1.011
3.231
Radiation dose
-0.425
0.316
1.811
1
0.178
0.654
0.352
1.214
Citation: He J, Zeng ZC, Shi SM, Yang P. Clinical features, outcomes and treatment-related pneumonitis in elderly patients with esophageal carcinoma. World J Gastroenterol 2014; 20(36): 13185-13190