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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 28, 2014; 20(36): 13146-13152
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13146
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13146
Variables | Patients |
Age, yr | 49 (16) |
Male gender | 52.5% |
BMI, kg/m2 | 23.5 (3.6) |
AST, IU/mL | 82 (71) |
ALT, IU/mL | 55 (48) |
gGT, IU/mL | 46 (57) |
Platelets, 109 L | 182 (90) |
APRI index | 0.4 (0.6) |
Basal HCV RNA, log IU/mL | 6 (1.1) |
Fibrosis (stiffness) | 6.7 (19) |
Fibrosis Metavir | |
F0-F1-F2 | 20 (25) |
F3-F4 | 59 (75) |
IL28B SNP rs8099917 | |
TT | 59 (50) |
TG | 56 (47) |
GG | 3 (3) |
IL28B SNP rs12979860 | |
CC | 30 (25) |
CT | 73 (62) |
TT | 15 (13) |
HCV RNA decline < 1 log10 IU/mL w4 | 26 (22) |
rs8099917_G*/rs12979860_** | 21 (81) |
rs8099917_TT/rs12979860_T* | 3 (11) |
rs8099917_TT/rs12979860_CC | 2 (8) |
Therapy outcome | |
R | 53 (55) |
NR | 65 (45) |
Baseline factors | Univariate | Multivariate | ||||
HCV RNA drop <1 log10: w4 | HCV RNA drop≥log10: w4 | P value | OR | 95%CI | P value | |
(n = 26) | (n = 92) | |||||
Age, yr | 49 (14) | 49 (18) | NS | - | - | NS |
Male gender | 15 (26) | 47 (74) | NS | - | - | NS |
BMI, kg/m2 | 23 (2) | 24 (4) | NS | - | - | - |
AST, IU/mL | 90 (46) | 67 (74) | 0.032 | 1.01 | 0.99-1.02 | NS |
ALT, IU/mL | 73 (60) | 49 (44) | 0.002 | 0.97 | 0.95-0.99 | 0.018 |
gGT, IU/mL | 68 (71) | 39 (43) | 0.001 | 0.99 | 0.98-0.99 | 0.009 |
Platelets, 109 L | 151 (93) | 196 (83) | 0.019 | - | - | NS |
APRI index | 0.6 (1.2) | 0.4 (0.6) | 0.033 | - | - | NS |
Basal HCV RNA, log IU/mL | 6.1 (0.8) | 6 (1.1) | NS | - | - | - |
Fibrosis F3/F4 | 11 (58) | 48 (80) | NS | - | - | NS |
IL28B rs8099917_TG/GG | 21 (81) | 38 (41) | < 0.001 | 7.90 | 1.99-31.18 | 0.003 |
IL28B rs12979860_CT/TT | 23 (88) | 65 (71) | NS | - | - | NS |
IL28B polymorphisms | Sn | Sp | PPV | NPV | LR |
rs8099917_TT | 59% | 81% | 91% | 36% | 3.05 |
rs12979860_CC | 29% | 88% | 90% | 26% | 2.54 |
rs8099917_TT or rs12979860_CC | 29% | 92% | 93% | 27% | 3.82 |
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Citation: Rosso C, Abate ML, Ciancio A, Strona S, Caviglia GP, Olivero A, Touscoz GA, Rizzetto M, Pellicano R, Smedile A.
IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients. World J Gastroenterol 2014; 20(36): 13146-13152 - URL: https://www.wjgnet.com/1007-9327/full/v20/i36/13146.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i36.13146