Parameters of a severe disease course in ulcerative colitis

Table 1 Patient characteristics

Patient characteristics	n (%)
Age at diagnosis (yr)	262 (34)
Gender
Male	127 (48.5)
Female	135 (51.5)
Extent of the disease
Proctitis	43 (16.4)
Proctosigmoiditis	47 (17.9)
Left-sided colitis	50 (19.1)
Pancolitis	114 (43.5)
Unknown	8 (3.0)
Extraintestinal manifestations
Eyes	2 (0.8)
Skin	6 (2.3)
Joints	50 (19.1)
Immunosuppressive therapy
Azathioprine	98 (94.2)
6-Mercaptopurine	23 (22.1)
Infliximab	36 (34.6)
Adalimumab	3 (2.9)
Golimumab	1 (1.0)
Methotrexate	3 (2.9)
Miscellaneous	12 (11.5)
Reason for IT
Steroid-refractory disease course	40 (38.4)
Chronic-active disease course	31 (29.8)
Steroid-dependent disease course	27 (26.0)
Miscellaneous	6 (5.8)

IT: Immunosuppressive treatment.

Table 2 Independent parameters associated with a severe course of ulcerative colitis, predicting the risk for subsequent necessity of immunosuppressive therapy (multivariate analysis)

Parameter	OR	95%CI	P value
Age at diagnosis	0.981 (per year)	0.967-0.995	0.009
Gender (female)	1.3	0.9-2.0	0.156
Steroid therapy at diagnosis	2.4	1.6-3.7	< 0.001
Hospitalisation at diagnosis	2.5	1.5-4	< 0.001
Extent of the disease			< 0.001
Proctitis	1
Procto-sigmoiditis	3.5	1.4-8.6	0.007
Left-sided colitis	5.3	1.6-15.3	0.002
Pancolitis	6.1	2.1-17.5	0.001
Result of steroid therapy			< 0.001
No steroids	1
Remission	5.2	1.4-20.3	0.016
Response	15.3	4.7-50	< 0.001
Steroid-dependent	50.8	15.2-170	< 0.001
Steroid-refractory	34.8	10.5-114.8	< 0.001