Minireviews
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 21, 2014; 20(35): 12526-12532
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12526
Table 1 Brief summary of necroptosis and necrostatin-1 effects in different liver disease models
Disease modelProbable necroptosis inducerDownstream signalingNec-1 effectsRef.
Ethanol induced liver injuryTNF-αJNK acts downstream of RIP3No effect[16]
Ethanol induced liver injuryTNF-αNo informationNo information[31]
APAP-induced liver toxicityUnknownJNK acts downstream of RIP3Protective[17]
APAP-induced liver toxicityUnknownNo informationProtective[32]
APAP-induced liver toxicityUnknownJNK acts downstream of RIP1Protective[15]
Con-A induced hepatitis modelTRAILPARP-1 acts downstream of RIP3Protective[33]
Con-A-induced hepatitisUnknownNo informationProtective[34]
Liver sepsis modelFasLNo informationHepatotoxic[25]