Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer

Table 1 Correlation between miR-193a-5p expression and clinicopathological factors of colorectal cancer

Variable	miR-193a-5p expression		P value
	Low (n = 56)	High (n = 55)
Age (yr)	61.9 ± 13.9	62.3 ± 11.9	0.298
Gender			0.924
Male	28	28
Female	28	27
Tumor size			0.768
≤ 5 cm	26	24
> 5 cm	30	31
Degree of differentiation			0.053
Well and moderate	38	46
Poor	18	9
Venous invasion			0.008b
Negative	43	52
Positive	13	3
Depth of invasion			0.484
T1, T2	12	11
T3, T4	44	44
Lymph node metastasis			< 0.001b
Absent	19	37
Present	37	18
Location			0.921
Colon	27	26
Rectum	29	29

^bP < 0.01 vs control group. CRC: Colorectal cancer; T: Tumor.

Table 2 Univariate analysis of clinicopathological factors for overall survival of colorectal cancer patients

Variable	Cases	HR	95%CI	P value
Gender			0.582-1.874	0.885
Male	56	1
Female	55	1.004
Age (yr)			0.820-2.738	0.189
≤ 60	51	1
< 60	60	1.498
Tumor size			0.921-3.124	0.090
≤ 5 cm	50	1
> 5 cm	61	1.696
Differentiation			0.852-3.098	0.140
Well, moderate	84	1
Poor	27	1.625
Venous invasion			2.058-7.781	< 0.001b
Negative	95	1
Positive	16	4.002
Depth of invasion			1.494-15.589	0.009b
T1, T2	23	1
T3, T4	88	4.826
Location			0.673-1.945	0.619
Rectum	58	1
Colon	53	1.144
Lymph node metastasis			3.194-13.937	< 0.001b
Absent	56	1
Present	55	6.672
miR-193a-5p expression			1.340-4.653	0.004b
High	55	1
Low	56	2.497

^bP < 0.01 vs control group. T: Tumor.

Table 3 Multivariate analysis of clinicopathological factors for overall survival of colorectal cancer patients

Variable	Cases	HR	95%CI	P value
Venous invasion			0.799-3.230	0.183
Negative	95	1
Positive	16	1.607
Depth of invasion			1.087-11.793	0.036a
T1, T2	23	1
T3, T4	88	3.58
Lymph node metastasis			1.906-9.319	< 0.001b
Absent	56	1
Present	55	4.214
miR-193a-5p expression			1.070-3.993	0.031a
High	55	1
Low	56	2.067

^aP < 0.05 vs control group;

^bP < 0.01 vs control group. T: Tumor.