Chronic permanent hypoxemia predisposes to mild elevation of liver stiffness

Table 1 Caracteristcs of pataients with cyanotic cardiopathy

Patients	Age (yr)	Diagnosis	Oxygen saturation	Liver stiffness (kPa)
1	33	Transposition of the great vessels	80%	7. 2
2	20	Tricuspid atresia, malposition of the great vessels and pulmonary atresia	86%	5.9
3	25	Fallot Tetralogy	87%	6.1
4	22	tricuspid atresia + malposition of the great vessels + interventricular communication	87%	4.0
5	32	Fallot Tetralogy	97%	6.5
6	20	Double outlet right ventricle with severe pulmonary stenosis.	90%	3.7
7	20	Double outlet right ventricle + pulmonary atresia	78%	7.8
8	42	Fallot Tetralogy	76%	6.4
9	24	Fallot Tetralogy	87%	4.8
10	26	Fallot Tetralogy	85%	6.9

Table 2 Characteristics of patients with cyanotic cardiopathy and control

	Patients w cyanotic cardiopathy	Control	P value
Case (male/female)	3/7	3/7
Age (yr)	26.4	27.1	0.540
BMI (kg/m2)	19.21 ± 4.8	18.64 ± 2.52	0.460
AST (IU)	23.12 ± 7.33	23.75 ± 4.94	0.370
ALT (IU)	23.9 ± 6.93	24.9 ± 5.43	0.080
Cholesterolg (/L)	1.22 ± 0.24	1.25 ± 0.26	0.830
Triglycerideg (/L)	0.85 ± 0.23	0.98 ± 0.18	0.910
Gylcemiag (/L)	0.97 ± 0.09	0.92 ± 0.01	0.830
GGT (IU)	39.9 ± 18.65	41.1 ± 13.39	0.330
Liver stiffness (kPa)	5.93 ± 135	4.74 ± 0.40	0.008
Saturation (%)	85.4 ± 6.1	99.5 ± 0.52	0.005

BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase.

Table 3 Relationship between liver stiffness and other factors in all participants

	Correlation coefficient (r)	P value
Glycemia	0.11	0.63
GOT	0.07	0.76
GPT	-0.19	0.39
GGT	0.009	0.97
T. cholesterol	0.17	0.45
Triglyceridemia	-0.21	0.35
Saturation	-0.63	0.002

GOT: Glutamate oxaloacetate transaminase; GPT: Gamma-pyruvate transaminase; GGT: Gamma-glutamyltransferase.