Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity?

Table 1 Clinical and pathological features of eosinophilic esophagitis, proton pump inhibitor responsive esophageal eosinophilia, and gastroesophageal reflux disease

	EoE	PPI-REE	GERD
Clinical Presentation	Upper GI symptoms, NS	Upper GI Symptoms, NS	Upper GI Symptoms, NS
PPI response after 8 wk therapy	No response (H/S)	Positive response (H/S)	Positive response (H/S)
Endoscopy	Non-specific findings	Non-specific findings	Non-specific findings
Ambulatory pH testing	Negative	Negative or unknown	Positive
Histology	> 15 Eos/hpf, OIEB	> 15 Eos/hpf, OIEB	Generally < 7, but can be > 15 Eos/hpf, OIEB
	PORB
Etiology	Allergy related?	Unknown	Reflux
Molecular Features	Eotaxin 3 mRNA increased	Unknown	Eotaxin-3 mRNA increased

GERD: Gastroesophageal reflux disease; PPI-REE: Proton pump inhibitor responsive esophageal eosinophilia; EoE: Eosinophilic esophagitis; H: Histologic; S: Symptomatic; NS: Non-specific; PORB: Persistent on repeat biopsy after PPI therapy; OIEB: On initial endoscopic biopsy.