Postprandial response of bone turnover markers in patients with Crohn’s disease

Table 1 Components of Crohn’s disease activity index¹

Clinical or laboratory variable	Weighting factor
Number of liquid or soft stools each day for seven days	× 2
Abdominal pain (graded from 0-3 on severity) each day for seven days	× 5
General well being, subjectively assessed from 0 (well) to 4 (terrible) each day for seven days	× 7
Presence of complications1	× 20
Taking diphenoxylate and atropine (lomotil) or opiates for diarrhea	× 30
Presence of an abdominal mass (0 as none, 2 as questionable, 5 as definite)	× 10
Hematocrit of < 0.47 in men and < 0.42 in women	× 6
Percentage deviation from standard weight	× 1

¹The index consists of eight factors, each summed after adjustment with a weighting factor. Remission of Crohn's disease is defined as Crohn’s disease activity index below 150.

Table 2 Demographic and laboratory values in patients with Crohn’s disease and healthy subjects n (%)

	Healthy subjects	Crohn’s disease	P value
Total number	45	59	-
Male	29 (64)	38 (64)	-
Premenopausal women	8 (17)	10 (17)	-
Age (yr)	35.64 ± 2	37.7 ± 1.8	NS
BMI (kg/cm2)	27.1 ± 0.9	27 ± 0.28	NS
Patients with active disease	-	23 (39)	-
Disease duration (yr)	-	7 ± 2.3	-
TSH (mIU/L)	1.74 ± 0.15	1.6 ± 0.79	NS
PTH (pmol/L)	4 ± 0.2	4.2 ± 0.12	NS
25-OH vitamin D (nmol/L)	64.8 ± 3.2	31.7 ± 3	< 0.001
Serum calcium (mmol/L)	2.2 ± 0.1	2.5 ± 0.08	NS
Serum phosphate (mmol/L)	1.1 ± 0.05	1.1 ± 0.16	NS
Glucose (mmol/L)	5.1 ± 0.1	4.5 ± 0.7	NS
Serum creatinine (μmol/L)	62 ± 1.9	71 ± 2.2	NS

TSH: Serum thyrotropin; PTH: Parathyroid hormone; NS: Not significant; BMI: Body mass index.