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World J Gastroenterol. Jul 21, 2014; 20(27): 9191-9199
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9191
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9191
Table 1 Characteristics of studies included in the meta-analysis
Ref. | Country | Ethnicity | Study design | Detected target | No. of cases detected for Notch1 | No. of controls detected for Notch1 | No. of cases detected for Hes1 | No. of controls detected for Hes1 | No. of cases detected for Jagged1 | No. of controls detected for Jagged1 |
Gou et al[7] | China | Asians | HCC | Notch1 | 108 | NC | - | - | - | - |
Huang et al[8] | China | Asians | HCC | Notch1 | 68 | 28 | - | - | - | - |
Kang et al[9] | South Korea | Asians | HCC | Notch1, Notch3, Jagged1, Jagged2, Hes1 | 103 | NC | 103 | NC | 103 | NC |
Li et al[10] | China | Asians | HCC | Notch1 | 168 | 27 | - | - | - | - |
Liu et al[11] | China | Asians | HCC | Notch1 | 317 | NC | - | - | - | - |
Piazzi et al[12] | Italy | Caucasians | HCC | DLL1 | - | - | - | - | - | - |
Sun et al[13] | China | Asians | HCC | Notch1, Notch2, Hes1 | 74 | 10 | 74 | 10 | - | - |
Wang et al[14] | China | Asians | HCC | Notch1, Hes1, NICD | 72 | 16 | 72 | 16 | - | - |
Yang et al[15] | China | Asians | HCC | Notch1 | 135 | 27 | - | - | - | - |
Yang et al[16] | China | Asians | HCC | Notch1, Jagged1, DLL1 | 63 | 63 | - | - | 63 | 63 |
Yeh et al[17] | Taiwan, China | Asians | HCC | Notch1, Jagged1 | 90 | NC | - | - | 96 | NC |
Zhang et al[18] | China | Asians | HCC | Notch1, DLL4 | 45 | 25 | - | - | - | - |
Zhang et al[19] | China | Asians | HCC | Notch1 | 54 | 54 | - | - | - | - |
Zhou et al[20] | China | Asians | HCC | Jagged1, Notch1 | 60 | NC | - | - | 60 | 20 |
Ishigami et al[21] | Japan | Asians | HCC | DLL4 | - | - | - | - | - | - |
Table 2 Meta-analysis of Notch1 and gastric cancer
Stratification of gastric cancer | No. of participants | OR (95%CI) | Statistical method | P value | Ref. |
Gender: | 1040 | 1.21 (0.92-1.59) | Fixed | 0.18 | 9[8-11,15,17-20] |
Male vs female | |||||
Age (yr): | 607 | 1.36 (0.96-1.91) | Fixed | 0.08 | 4[8,10,11,19] |
≤ 60 vs > 60 | |||||
Location: | 589 | 0.62 (0.43-0.91) | Fixed | 0.01a | 5[8,11,17,19,20] |
Cardia vs noncardia | |||||
Tumor size: | 634 | 0.68 (0.49-0.94) | Fixed | 0.02a | 5[8,11,15,19,20] |
≤ 5 cm vs > 5 cm | |||||
Lauren's classification: | 680 | 1.45 (1.03-2.03) | Fixed | 0.03a | 5[9,11,13,15,17] |
Intestinal vs diffuse | |||||
Histological differentiation: | 1220 | 1.42 (0.85-2.37) | Random | 0.17 | 11[7-11,14,15,17-20] |
Well/moderate vs poor/undifferentiated | |||||
Lymphovascular invasion: | 258 | 0.49 (0.28-0.87) | Fixed | 0.01a | 2[10,17] |
Negative vs positive | |||||
T stage: | 453 | 0.71 (0.24-2.09) | Random | 0.54 | 5[7,10,14,18,20] |
T1-2 vs T3-4 | |||||
N stage: | 1220 | 1.07 (0.57-2.00) | Random | 0.83 | 11[7-11,14,15,17-20] |
N0 vs N1-3 | |||||
Distal metastasis: | 285 | 0.33 (0.14-0.78) | Fixed | 0.01a | 3[10,14,18] |
Negative vs positive | |||||
TNM stage: | 567 | 0.91 (0.53-1.57) | Random | 0.74 | 7[8,9,14,15,17-19] |
Stages I-II vs III-IV |
Table 3 Meta-analysis of other components of Notch signaling pathway and gastric cancer
Stratification of gastric cancer | Notch2 | Notch3 | Jagged1 | Jagged2 | DLL4 | Hes1 | ||||||
OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | |
Tumor tissue vs normal tissue | 292.00 (23.75-3589.39) | < 0.01a | - | - | 0.94 (0.00-254.96) | 0.98 | - | - | 3.84 (2.52-5.83) | < 0.01a | 14.31 (4.11-49.87) | < 0.01a |
Gender: | - | - | 1.01 (0.46-2.26) | 0.97 | 1.26 (0.36-4.39) | 0.36 | 2.90 (0.76-11.02) | 0.12 | 1.03 (0.57-1.86) | 0.93 | 1.05 (0.47-2.35) | 0.90 |
Male vs female | ||||||||||||
Age (yr): | - | - | 0.75 (0.30-1.88) | 0.54 | 1.19 (0.48-2.94) | 0.70 | 0.17 (0.02-1.40) | 0.10 | 0.52 (0.13-2.16) | 0.37 | 1.13 (0.45-2.81) | 0.80 |
≤ 55 vs > 55 | ||||||||||||
Location: | - | - | - | - | 0.63 (0.26-1.50) | 0.30 | - | - | - | - | - | - |
Cardia vs noncardia | ||||||||||||
Lauren's classification: | 0.60 (0.02-15.19) | 0.76 | 2.61 (1.17-5.84) | 0.02a | 2.02 (1.11-3.69) | 0.02a | 3.97 (1.17-13.46) | 0.03a | - | - | 1.71 (0.88-3.30) | 0.11 |
Intestinal vs diffuse | ||||||||||||
Histological differentiation: | - | - | 2.04 (0.89-4.67) | 0.09 | 2.18 (1.23-3.86) | < 0.0a | 1.36 (0.44-4.18) | 0.60 | 0.89 (0.52-1.54) | 0.69 | 1.78 (0.95-3.34) | 0.07 |
Well/moderate vs poor/undifferentiated | ||||||||||||
T stage: | - | - | 2.40 (0.73-7.92) | 0.15 | 0.50 (0.03-8.54) | 0.63 | 3.70 (1.05-13.08) | 0.04a (T1 vs T2-4) | 0.29 (0.16-0.54) | < 0.01a | 1.72 (0.49-6.00) | 0.39 (T1 vs T2-4) |
T1-2 vs T3-4 | ||||||||||||
N stage: | - | - | 1.84 (0.71-4.75) | 0.21 | 0.82 (0.44-1.50) | 0.51 | 0.91 (0.23- 3.55) | 0.89 | 0.12 (0.06-0.23) | < 0.01a | 0.39 (0.04-4.38) | 0.45 |
N0 vs N1-3 | ||||||||||||
Distal metastasis: | - | - | - | - | - | - | - | - | 0.55 (0.10-3.00) | 0.49 | 1.76 (0.36-8.51) | 0.48 |
Negative vs positive | ||||||||||||
TNM stage: | - | - | 1.19 (0.54-2.63) | 0.67 | 0.78 (0.42-1.42) | 0.41 | 1.32 (0.44-3.98) | 0.62 | 0.15 (0.03-0.80) | 0.03a | 0.70 (0.15-3.36) | 0.66 |
Stages I-II vs III-IV |
- Citation: Du X, Cheng Z, Wang YH, Guo ZH, Zhang SQ, Hu JK, Zhou ZG. Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature. World J Gastroenterol 2014; 20(27): 9191-9199
- URL: https://www.wjgnet.com/1007-9327/full/v20/i27/9191.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i27.9191