Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain

Table 1 Pancreatic disease entities and the severity of pain n (%)

Diagnosis	Pain			P value
	Pain 0	Pain I	Pain II
Pancreatic cancer	211	154	65	< 0.0001
	(49.0)	(35.8)	(15.1)
Chronic pancreatitis	54	140	101
	(18.3)	(47.5)	(34.2)
Serous cystadenoma	18	12	1	< 0.02
	(58.0)	(38.7)	(3.2)
Mucinous cystadenoma	4	11	4
	(21.0)	(57.9)	(21.0)
Non-invasive IPMN	19	20	2	0.235
	(46.3)	(48.8)	(4.9)
Invasive IPMN	11	18	5
	(32.4)	(52.9)	(14.7)
Low stage neuroendocrine neoplasia	9	5	0	0.565
	(64.3)	(35.7)	(0.0)
High stage neuroendocrine neoplasia	23	13	3
	(59.0)	(33.3)	(7.7)
AmpC	27	13	4
	(61.4)	(29.6)	(9.1)
Total	322	246	84
	(49.4)	(37.7)	(12.9)

IPMN: Intraductal papillary mucinous neoplasia.

Table 2 Intrapancreatic localization of all included pancreatic tumors n (%)

Diagnosis	Tumor localization
	Pancreatic head	Pancreatic body	Pancreatic tail	> 1 pancreatic area	Pancreas unspecified	Papilla vateri
Pancreatic cancer	362	50	44	11	1	1
	(77.2)	(10.7)	(9.4)	(2.4)	(0.2)	(0.2)
Serous cystadenoma	8	9	9	4	1	0
	(25.8)	(29.0)	(29.0)	(12.9)	(3.2)	(0.0)
Mucinous cystadenoma	2	6	9	1	1	1
	(10.0)	(30.0)	(45.0)	(5.0)	(5.0)	(5.0)
Non-invasive IPMN	33	2	3	6	2	2
	(68.8)	(4.2)	(6.3)	(12.5)	(4.2)	(4.2)
Invasive IPMN	26	3	4	4	0	0
	(70.3)	(8.1)	(10.8)	(10.8)	(0.0)	(0.0)
Low stage neuroendocrine neoplasia	5	4	4	2	2	1
	(27.8)	(22.2)	(22.2)	(11.1)	(11.1)	(5.6)
High stage neuroendocrine neoplasia	16	7	14	1	2	4
	(36.4)	(15.9)	(31.8)	(2.3)	(4.5)	(9.1)
Ampullary cancer	0	0	0	0	0	51
	(0.0)	(0.0)	(0.0)	(0.0)	(0.0)	(100)
Total	452	81	87	29	9	60
	(63.0)	(11.3)	(12.1)	(4.0)	(1.3)	(8.4)

IPMN: Intraductal papillary mucinous neoplasia.