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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 21, 2014; 20(27): 8928-8938
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8928
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8928
Table 1 Sensitivities and specificities of various studies that took blood samples n (%)
Source | Method | Marker | Sensitivity | Specificity | Ref. |
Serum | MSP | CDKN2A (p16) | 14/52 (27) | 44/44 (100) | [32] |
Serum | RT-PCR | CEA | 51/121 (42) | 27/33 (82) | [56] |
Serum | RT-PCR | CK20 | 22/99 (22) | 150/150 (100) | [38] |
Serum | qPCR | miR-92 | 80/90 (89) | 35/50 (70) | [84] |
Serum | CellSearch | EpCAM | 20/74 (27) | 228/246 (93) | [88] |
Serum | CLIA | CEA | 188/429 (44) | 184/201 (92) | [112] |
Table 2 Comparison of biomarkers for detection of metastatic colorectal cancer cells
Marker | Stable | Amplifiable | Widely reported | FDA approval | False negative | False positive | Ref. |
DNA methylation | ● | ● | ● | [16] | |||
mRNA | ● | ● | ● | [7] | |||
Micro RNA | ● | ● | [81] | ||||
CellSearch (EpCAM) | ● | ● | ● | [39] | |||
Genetic mutation | ● | ● | ● | [15] |
- Citation: Kamiyama H, Noda H, Konishi F, Rikiyama T. Molecular biomarkers for the detection of metastatic colorectal cancer cells. World J Gastroenterol 2014; 20(27): 8928-8938
- URL: https://www.wjgnet.com/1007-9327/full/v20/i27/8928.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i27.8928