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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 21, 2014; 20(27): 8796-8806
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8796
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8796
Table 1 Irritable bowel syndrome subtypes
Subtype | Definition |
(symptoms classified using Bristol stool form scale) | |
IBS with constipation (IBS-C) | > 25% of stools are hard or lumpy and < 25% of stools are loose/mushy or watery |
IBS with diarrhea (IBS-D) | > 25% of stools are loose/mushy or watery stools and < 25% are hard or lumpy |
Mixed IBS (IBS-M) | > 25% of stools are loose/mushy or watery stools and > 25% and hard or lumpy |
Unsubtyped IBS | insufficient abnormality of stool consistency to meet criteria for IBS-C, D, or M (in the absence of antidiarrheals or laxatives) |
Table 2 Response rates for lubiprostone 12 wk phase III irritable bowel syndrome with constipation studies
Lubiprostone | Placebo | P value | |
Overall responder | 17.90% | 10.10% | 0.001 |
Month 1 | 10.80% | 7.50% | 0.078 |
Month 2 | 18.20% | 11.40% | 0.003 |
Month 3 | 22.00% | 14.50% | 0.003 |
Table 3 Adverse events for lubiprostone phase III irritable bowel syndrome with constipation studies
Lubiprostone | Placebo | Lubiprostone | |
12 wk | 12 wk | 36 wk | |
Serious | 1% | 1% | 1.90% |
Treatment related | 22% | 21% | 25.40% |
Nausea | 8% | 4% | 11% |
Diarrhea | 6% | 4% | 11% |
Abdominal distension | 2% | 2% | 3.70% |
Discontinuation due to ADR | 5% | 7% | 4% |
Table 4 Probiotic strains
Clinical condition | Effectiveness | Specific strain |
IBS | B | Bifidobacterium infantis B5624 |
IBS | B | VSL33 (composite containing multiple strains): |
3 strains of Bifidobacterium: | ||
Bifidobacterium longum | ||
Bifidobacterium finfantis | ||
Bifidobacterium breve | ||
4 strains of Lactobacillus: | ||
Lactobacillus acidophilus | ||
Lactobacillus casei | ||
Lactobacillus bulgaricus | ||
Lactobacillus plantarum | ||
1 strain of Streptococcus salivarius, subspecies | ||
Thermophilus | ||
IBS | C | Bifidobacterium animalis |
IBS | C | Lactobacillus plantarum 299V |
- Citation: Wall GC, Bryant GA, Bottenberg MM, Maki ED, Miesner AR. Irritable bowel syndrome: A concise review of current treatment concepts. World J Gastroenterol 2014; 20(27): 8796-8806
- URL: https://www.wjgnet.com/1007-9327/full/v20/i27/8796.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i27.8796