Copyright
©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 7, 2014; 20(25): 8229-8236
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8229
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8229
Table 1 Four siRNA duplexes targeting Girdin
| siRNA | Synthetic siRNA sequence |
| siRNA1 | Sense: CCAGAAUGUACCGAGAUGAUU |
| Antisense: UCAUCUCGGUACAUUCUGGUU | |
| siRNA2 | Sense: CUUCAUUAGUUCUGCGGGAUU |
| Antisense: UCCCGCAGAACUAAUGAAGUU | |
| siRNA3 | Sense: GGACCAACCUUGAUGAAUAUU |
| Antisense: UAUUCAUCAAGGUUGGUCCUU | |
| siRNA4 | Sense: CAAGAGUUGAGGAAUUAAAUU |
| Antisense: UUUAAUUCCUCAACUCUUGUU | |
| scramble siRNA | Sense: GAGGCGAAACGCTAAATATCT |
| Antisense: AGATATTTAGCGTTTCGCCTC |
Table 2 Top 10 downregulated and upregulated genes in Lv-Girdin shRNA infected DLD1 cell line vs Lv-scramble shRNA infected DLD1 cell lines
| Gene name | P value | Ratio |
| Downregulated | ||
| TOP2B | 0.000148 | 0.780296 |
| EIF3E | 0.000154 | 0.794333 |
| SCARNA9 | 0.000166 | 0.768316 |
| SEMA3A | 0.000227 | 0.781830 |
| IKZF2 | 0.000296 | 0.712167 |
| KIT | 0.000311 | 0.792173 |
| MIR34A | 0.000358 | 0.783264 |
| LRRC37A4 | 0.000366 | 0.661987 |
| LRRC37A4 | 0.000391 | 0.66294 |
| ARHGAP18 | 0.000400 | 0.756169 |
| Upregulated | ||
| PPP1R15A | 0.000114 | 1.504745 |
| TAP2 | 0.000117 | 1.217997 |
| FOSL2 | 0.000151 | 1.228042 |
| KRTAP2-1 | 0.000170 | 1.588156 |
| TNFRSF9 | 0.000170 | 5.843542 |
| BCL3 | 0.000185 | 1.369511 |
| LCN2 | 0.000195 | 5.641935 |
| CYB561D2 | 0.000196 | 1.203703 |
| SERPINE2 | 0.000204 | 1.247110 |
| RAB15 | 0.000205 | 1.353464 |
- Citation: Zhang YJ, Li AJ, Han Y, Yin L, Lin MB. Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin. World J Gastroenterol 2014; 20(25): 8229-8236
- URL: https://www.wjgnet.com/1007-9327/full/v20/i25/8229.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i25.8229
