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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 14, 2014; 20(22): 7011-7018
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7011
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7011
Table 1 Clinical and biochemical characteristics of cirrhotic patients
Variable | Total (n = 100) | NGT (n = 30) | SAGT (n = 70) |
Age, yr | 53.9 ± 11.8 | 49.0 ± 12.0 | 56.0 ± 11.11 |
BMI, kg/m2 | 26.9 ± 4.2 | 26.4 ± 4.40 | 27.21 ± 4.15 |
Males | 60 (60) | 18 (60) | 42 (60) |
Etiology: Alcohol | 47 (47) | 14 (46.6) | 33 (47.1) |
HBV | 4 (4) | 1 (3.3) | 3 (4.2) |
HCV | 13 (13) | 2 (6.6) | 11 (15.7) |
Autoimmunity | 10 (10) | 3 (10) | 7 (10) |
Cryptogenic | 26 (26) | 10 (33.3) | 16 (22.8) |
Liver biopsy | 44 (44) | 13 (43.3) | 31 (44.2) |
Length of LC, mo | 21.6 + 27.6 | 21.4 ± 30.6 | 21.7 ± 33.2 |
Hemoglobin, g/dL | 11.8 ± 2.3 | 11.6 ± 2.1 | 11.9 ± 2.3 |
Platelets, × mm3 | 128140 ± 89501 | 159186 ± 112108 | 114834 ± 73269 |
INR | 1.3 ± 0.3 | 1.2 ± 0.3 | 1.36 ± 0.32 |
Creatinine, mg/dL | 0.8 ± 0.2 | 0.90 ± 0.33 | 0.83 ± 0.2 |
Albumin, g/dL | 3.2 ± 0.73 | 3.33 ± 0.71 | 3.21 ± 0.74 |
ALT, UI/L | 46.5 ± 40.8 | 48.9 ± 53.9 | 45.4 ± 34.0 |
Total bilirubin, mg/dL | 1.71 ± 0.90 | 1.55 ± 0.88 | 1.78 ± 0.91 |
Fasting plasma insulin, μU/mL | 15.9 ± 10.2 | 11.9 ± 7.6 | 18.2 ± 113 |
HOMA2 score | 2.67 ± 1.6 | 2.36 ± 1.46 | 4.6 ± 3.34 |
Child-Pugh A | 47 (47) | 15 (50) | 32 (45.7) |
B | 53 (53) | 15 (50) | 38 (54.2) |
Child Pugh score | 6.8 ± 1.8 | 6.5 ± 1.61 | 6.82 ± 1.67 |
MELD score | 8.94 ± 4.8 | 8.3 ± 5.2 | 9.21 ± 4.63 |
Survival, d | 1237 | 1448 | 1116 |
(990-1925) | (1256-1925) | (990-1790)5 |
Table 2 Annual cumulated survival of cirrhotic patients n (%)
Year(s) | NGT (n = 30) | SAGT (n = 70) | P value (χ2test) |
1 | 2 (93) | 9 (87) | 0.36 |
2 | 4 (83.2) | 14 (79) | 0.34 |
3 | 4 (83.2) | 23 (51.4) | 0.04 |
4 | 4 (83.2) | 24 (47.5) | 0.03 |
5 | 5 (71.6) | 26 (31.7) | 0.02 |
Table 3 Causes of death n (%)
Cause | Total (n = 31) |
Variceal bleeding | 8 (25.8) |
Liver failure | 6 (19.3) |
SBP e infection | 5 (16.2) |
Hepatorenal syndrome | 5 (16.2) |
HCC | 4 (12.9) |
Renal impairment | 2 (6.4) |
Cardiovascular | 1 (3.2) |
Table 4 Univariate and multivariate analyses: Independent predictors of death
Variable | HR | 95%CI | P value | HR | 95%CI | P value |
Creatinine | 1.6 | 1.2-40.2 | 0.030 | 2.62 | 0.5-3.46 | 0.650 |
Albumin | 3.4 | 1.8-22.3 | 0.015 | 6.3 | 0.4-32.1 | 0.180 |
INR | 2.2 | 1.6-32.4 | 0.050 | 3.5 | 0.3-23.6 | 0.230 |
Child-Pugh B | 7.2 | 3.4-33.0 | 0.0003 | 8.2 | 2.0-28.5 | 0.020 |
Child Pugh score | 5.2 | 2.9-25.8 | 0.008 | 10.2 | 2.4-21.9 | 0.008 |
MELD score | 8.1 | 4.2-18.7 | 0.001 | 12.3 | 6.4-33.6 | 0.001 |
SAGT | 4.5 | 2.0-15.2 | 0.042 | 3.2 | 2.8-54.2 | 0.010 |
Fasting serum insulin | 1.2 | 1.0-33.5 | 0.040 | 3.2 | 0.1-27.3 | 0.320 |
- Citation: García-Compeán D, Jáquez-Quintana JO, Lavalle-González FJ, González-González JA, Muñoz-Espinosa LE, Villarreal-Pérez JZ, Maldonado-Garza HJ. Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis. World J Gastroenterol 2014; 20(22): 7011-7018
- URL: https://www.wjgnet.com/1007-9327/full/v20/i22/7011.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i22.7011