Role of hepatitis B virus DNA integration in human hepatocarcinogenesis

doi:10.3748/wjg.v20.i20.6236

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May 28, 2014 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2014; 20(20): 6236-6243
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6236

Table 1 Main integration sites in human genome and in hepatitis B virus DNA

Integration sites in host genome	HBV DNA
hTERT	3’ end of HBx
MLL	Pre-S2/S
RAR-b
CCNE1
Cyclin A2
FN1
ROCK1
SENP5
ANGPT1
PDGF receptor
Calcium signaling-related genes
Ribosomal protein genes
Epidermal growth factor receptor
Mevalonate kinase
Carboxypeptidase
Platelet growth factor receptor

HBV: Hepatitis B virus; HBx: Hepatitis B virus X protein.

Citation: Hai H, Tamori A, Kawada N. Role of hepatitis B virus DNA integration in human hepatocarcinogenesis. World J Gastroenterol 2014; 20(20): 6236-6243
URL: https://www.wjgnet.com/1007-9327/full/v20/i20/6236.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i20.6236