Histological changes of gastric mucosa after Helicobacter pylori eradication: A systematic review and meta-analysis

Table 1 Main characteristics of the 16 studies selected for meta-analysis

Ref.	Author, year (country)	Study arms, n				Histologic parameters
		Eradicated	Not eradicated	Follow-up in year	Medication	GA		IM
						Antrum	Corpus	Antrum	Corpus
[28]	Annibale B, 2000 (Italy)	25	7	0.5	BAM	Yes	Yes	Yes	Yes
		15	15	0.5	BAM
		15	15	1	BAM
[29]	Wambura C, 2004 (Japan)	107	118	1	L/A/C	Yes	Yes	Yes	Yes
		107	118	2	L/A/C
		107	118	3	L/A/C
[30]	Annibale B, 2002 (Italy)	8	0	0.5-1	BAM	Yes	Yes	Yes	Yes
		32	0	0.5-1	BAM
[31]	Kamada T, 2005 (Japan)	20	233	1	O/L/A/C	Yes	Yes	Yes	Yes
		1767		1	O/L/A/C
[32]	Tucci A, 1998 (Italy)	10	0	1	BAM	Yes	No	Yes	No
		8	2 (lost)	1	BAM
[33]	Sung JJ, 2000 (China)	226	245	1	OAC	Yes	Yes	Yes	Yes
[34]	Ito M, 2002 (Japan)	22	22	5	PPI/A/C	Yes	Yes	Yes	Yes
[35]	Lahner E, 2005 (Italy)	38	36	6.7	B-BTI	Yes	Yes	Yes	Yes
[36]	Toyokawa T, 2009 (Japan)	241	19	5	PPI/A/C	Yes	Yes	Yes	Yes
[37]	Ohkusa T, 2001 (Japan)	115	48	1-1.25	PPI/A/C	Yes	Yes	Yes	Yes
[38]	Iacopini F, 2003 (Italy)	10	0	1	OMC	Yes	No	Yes	No
[39]	Kamada T, 2003 (Japan)	37	8	3	OMC	Yes	No	No	No
[40]	Lu B, 2005 (China)	92	62	3	O/LAC	Yes	No	Yes	No
[41]	Ruiz B, 2001 (Colombia)	29	21	1	BAM	Yes	No	No	No
[42]	Yoshio O, 2004 (Japan)	59	0	1	O/A/C	Yes	Yes	Yes	Yes
[43]	Yamada T, 2003 (Japan)	87	29	0.83-4.17	PPI/A/C	Yes	Yes	Yes	Yes

A: Amoxicillin; B: Bismuth subcitrate; B-BTI: Bismuth-based triple regimen; C: Clarithromycin; GA: Gastric atrophy; IM: Intestinal metaplasia; L: Lansoprazole; M: Metronidazole; O: Omeprazole; PPI: Proton pump inhibitor; BAM: Bismuth subcitrate, Metronidazole and Amoxicillin; OMC: Omeprazole, Metronidazole and Clarithromycin.