Determining hepatitis C virus genotype distribution among high-risk groups in Iran using real-time PCR

Table 1 Frequency of hepatitis C virus infection among high-risk groups n (%)

High-risk group	Frequency	M/F
Addict	550 (62.2)	546/4
Thalassemia	38 (4.3)	17/21
Hemophilia	8 (0.9)	7/1
Kidney graft	4 (0.5)	2/2
Dialysis	6 (0.7)	5/1
Liver graft	3 (0.3)	1/2
Unknown	277 (31.3)	209/68
Total	886 (100.0)	787/99

Table 2 Distribution of hepatitis C virus genotypes among Iranian hepatitis C virus infected patients according to route of infection n (%)

High-risk group	Frequency	Undetectable	Gt1	Gt2	Gt3	Gt4	Gt1/2	Gt1/3
Addict	550	67 (12.2)	283 (51.5)	0 (0.0)	192 (34.9)	0 (0.0)	2 (0.4)	6 (1.1)
Thalassemia	38	15 (39.5)	17 (44.7)	0 (0.0)	6 (15.8)	0 (0.0)	0 (0.0)	0 (0.0)
Hemophilia	8	2 (25.0)	5 (62.5)	0 (0.0)	1 (12.5)	0 (0.0)	0 (0.0)	0 (0.0)
Kidney graft	4	1 (25.0)	2 (50)	0 (0.0)	1 (25.0)	0 (0.0)	0 (0.0)	0 (0.0)
Dialysis	6	1 (16.7)	4 (66.7)	0 (0.0)	0 (0.0)	1 (16.7)	0 (0.0)	0 (0.0)
Liver graft	3	1 (33.3)	2 (66.7)	0 (0.0)	0 (0.)	0 (0.0)	0 (0.0)	0 (0.0)
Unknown	277	64 (23.1)	140 (50.5)	3 (1.1)	67 (24.2)	3 (1.1)	0 (0.0)	0 (0.0)
Total	886	151 (17.0)	453 (51.1)	3 (0.3)	267 (30.1)	4 (0.5)	2 (0.2)	6 (0.7)

HCV: Hepatitis C virus.

Table 3 Comparison of illicit drug user age-groups in terms of hepatitis C virus genotypes n (%)

	Undetectable	Gt1	Gt2	Gt3	Gt4	Gt1/2	Gt1/3	Total
< 20	0 (0.0)	1 (33.3)	0 (0.0)	2 (66.66)	0 (0.0)	0 (0.0)	0 (0.0)	3 (0.57)
21-30	14 (11.02)	59 (46.45)	0 (0.0)	53 (41.73)	0 (0.0)	0 (0.0)	1 (0.78)	127 (24.47)
31-40	23 (10.95)	113 (53.80)	0 (0.0)	69 (32.85)	0 (0.0)	2 (0.95)	3 (1.42)	210 (40.46)
41-50	18 (16.36)	58 (52.72)	0 (0.0)	33 (30)	0 (0.0)	0 (0.0)	1 (0.9)	110 (21.19)
51-60	6 (11.53)	25 (48.07)	0 (0.0)	20 (38.46)	0 (0.0)	0 (0.0)	1 (1.92)	52 (10.01)
> 60	1 (5.88)	10 (58.82)	0 (0.0)	6 (35.29)	0 (0.0)	0 (0.0)	0 (0.0)	17 (3.27)
Total	62 (11.9)	266 (51.25)	0 (0.0)	183 (35.26)	0 (0.0)	2 (0.38)	6 (1.15)	519 (100.0)

Table 4 Comparison of hepatitis C virus genotypes in the addict and non-addict high-risk groups

Genotype	Non-addict	Addict
Gt1	50.7%	51.5%
Gt2	1.0%	0.0%
Gt3	22.0%	34.9%
Gt4	1.3%	0.0%
Gt1/2	0.0%	0.4%
G1/3	0.0%	1.1%
Unknown	25.0%	12.2%

Table 5 Important risk factors in Iranian illicit drug users n (%)

HCV infection	+Imprisonment and tattoo	+Imprisonment	+ No other risk factor	Total
Injection Drug Users	70	235	134	439 (80)
Non-Injection Drug Users	63	23	25	111 (20)
Total	133 (24)	265 (48)	159 (28)	550 (100)