Hepatitis B virus infection and intrahepatic cholangiocarcinoma

Table 1 Characteristic of case-control studies of hepatitis B virus infection and intrahepatic cholangiocarcinoma risk

Study	Study design	Dates	Cases		Controls		Source	OR (95%CI) for HBV infection (serum HBsAg, unless stated otherwise)
			Total	With exposure	Total	With exposure
Donato et al[24], 2001	Case-control	1995-2000	26	13%	824	5.5%	Hospital	2.7 (0.4-18.5)
Yamamoto et al[15], 2004	Case-control	1991-2002	50	4%	205	2%	Hospital	1.84 (0.34-10.11)
Shaib et al[11], 2005	Case-control	1993-1999	625	0.2%	90834	0.2%	Population	0.8 (0.1-5.9)
Choi et al[30], 2006	Case-control	2003-2004	51	7.8%	51	9.8%	Hospital	0.8 (0.2-3.02)
Shaib et al[12], 2007	Case-control	1992-2002	83	1.2%	236	0.4%	Hospital	2.9 (0.1-236.8)
								anti-HBc
								28.6 (3.9-1268.1)
Lee et al[19],2008	Case-control	2000-2004	622	13.5%	2488	5.0%	Hospital	2.3 (1.6-3.3)
Zhou et al[22], 2008	Case-control	2004-2006	312	48.4%	438	9.6%	Hospital	8.9 (5.97-13.19)
Tao et al[20], 2009	Case-control	1998-2008	61	27.9%	380	5.0%	Hospital	7.3 (3.1-17.2)
Lee et al[28],2009	Case-control	1991-2005	160	37.5%	160	13.8%	Hospital	4.99 (2.78-8.95)
Tanaka et al[23], 2010	Cohort	1991-1993		9.08%1		0.66%2	7.6 yr of follow-up	8.56 (1.33-55.20)
Zhou et al[21], 2010	Case-control	2003-2006	317	48.6%	634	6.6%	Hospital	9.67 (6.33-14.77)
Peng et al[26], 2011	Case-control	2002-2009	98	31.6%	196	12.8%	Hospital	2.75 (1.27-5.95)
Fwu et al[29], 2011	Cohort	1983-2000		0.43%3		0.09%4	6.91 yr of follow-up	4.80 (1.88-12.20)
Welzel et al[13], 2011 United States	Case-control	1993-2005	743	1.5%	195953	0.2%	Population	3.1 (1.43-6.58)
Chaiteerakij et al[27], 2013	Case-control	2000-2010	612	3.0%	594	3.0%	Hospital

¹Incidence rate of intrahepatic cholangiocarcinoma (ICC) per 100000 hepatitis B surface antigen (HBsAg)-seropositive person-years;

²Incidence rate of ICC per 100000 HBsAg and anti-hepatitis C virus-seronegative person-years;

³Incidence rate of ICC per 100000 HBsAg-seropositive woman-years;

⁴Incidence rate of ICC per 100000 HBsAg-seronegative woman-years. HBV: Hepatitis B virus; Anti-HBc: Hepatitis B core antibody.