Utility of serum TNF-α, infliximab trough level, and antibody titers in inflammatory bowel disease

Table 1 Demographic and clinical data of patients participating in the study

Therapy	IBD patients with loss of response, side effects, hypersensitivity(n = 6)	Control IBD patients(n = 1)
Mean age at diagnosis, yr	34.9 (17-67)	36.4 (17-66)
Mean disease duration at biological therapy, yr	7.1 (1-20)	7.7 (1-21)
CD/UC	19/17	17/14
Male/female	14/22	14/17
Previous biological therapy	22	15
Concomitant steroid therapy	5	3
Concomitant thiopurine therapy	18	16
Previous surgery	16	7
Active disease	25	0

CD: Crohn’s disease; UC: Ulcerative colitis; IBD: Inflammatory bowel disease.

Table 2 Serum infliximab and antibody levels in cases of antibody positivity

Patients	Serum IFX level (μg/mL)	ATI level (μg/mL)
1	2.75	3194.90
2	2.68	258.55
3	2.67	1056.25
4	2.66	3055.04
5	2.93	3712.82
6	2.26	3343.07
7	2.66	129.54
8	2.49	4540.33
9	12.40	58.92
10	2.66	3679.21
11	2.65	536.57
12	1.90	555.53
13	1.71	810.87
14	4.67	46.34

IFX: Infliximab; ATI: Antibody.