Prediction of Crohn’s disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort

Table 1 Number of surgical interventions according to nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene status

Surgical interventions	Pathogenic mutation positive (n = 8)	Pathogenic mutation negative (n = 22)
1	2	12
2	1	5
3	1	3
4	3	1
5	1	1

Table 2 Analysis of phenotypic characteristics of Crohn’s disease patients according to nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene status¹

Characteristics	3020insC mutation positive (n = 4)	3020insC mutation negative (n = 26)
Disease behaviour
Perforating	1	5
Stricturing	4	14
Inflammatory	3	7
Location of CD lesions
Small bowel	4	7
Ileocaecal	6	19
Colonic	1	7
Anorectal	1	1
Others	0	0
No of locations involved
1	4	13
2	4	7
3	0	2
4+	0	0
Extraintestinal manifestations	0	3

¹Some patients had more than one clinical variable. CD: Crohn’s disease.

Table 3 Comparison of allele frequencies of nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 mutations

Study	Population	NOD2/CARD15 mutation
		3020insC	Exon 8	Exon 4
Present study	Australian	13.3%	3%	16.7%
Hugot et al[4]	European	12%	6%	11%
Hampe et al[5]	German/British	16%	-	-
Vermeire et al[10]	Canadian	10.3%	5.2%	12.9%
Cavanaugh et al[13]	Australian	7%	2%	11%

NOD2/CARD15: Nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene.