Roles of sphincter of Oddi motility and serum vasoactive intestinal peptide, gastrin and cholecystokinin octapeptide

Table 1 Changes in sphincter of Oddi myoelectric activity in process of gallstone formation

Groups	Amplitude	Frequency
Control group	146.44 ± 81.09	15.86 ± 4.35
3-wk group	125.06 ± 59.76	10.38 ± 2.02a
6-wk group	112.02 ± 64.69	12.90 ± 4.39
9-wk group	77.81 ± 27.17	15.10 ± 4.13
12-wk group	71.72 ± 35.10	13.70 ± 4.15

^aP < 0.05 vs the control group.

Table 2 Sphincter of Oddi manometry in process of gallstone formation

Group	SO basal pressure (mmHg)	Common bile duct pressure (mmHg)	Amplitude of SO	Frequency of SO
Control group	25.19 ± 7.77	22.35 ± 7.60	8.52 ± 2.27	11.57 ± 2.94
3-wk group	29.72 ± 5.59	25.78 ± 5.30	11.83 ± 3.32	8.17 ± 3.54
6-wk group	27.07 ± 11.11	24.29 ± 10.79	8.35 ± 2.82	10.50 ± 5.20
9-wk group	33.09 ± 13.65	29.19 ± 13.84	11.71 ± 2.37	7.50 ± 1.73a
12-wk group	40.56 ± 11.81a	38.51 ± 11.57a	6.15 ± 2.97	8.20 ± 2.59

^aP < 0.05 vs the control group. SO: Sphincter of Oddi.

Table 3 Changes in process of pigment gallstone formation

Group	3-wk	6-wk	9-wk	12-wk
VIP
Control (pg/mL)	5.96 ± 2.97	4.37 ± 1.00	7.70 ± 2.08	8.68 ± 0.65
Pigment gallstone (pg/ mL)	10.35 ± 2.59	14.70 ± 3.41a	17.02 ± 6.26	25.30 ± 6.56a
Gastrin
Control (pg/mL)	17.83 ± 2.35	18.56 ± 5.77	17.42 ± 6.39	19.41 ± 4.58
Pigment gallstone(pg/mL)	2.44 ± 0.78b	8.51 ± 0.33	36.51 ± 12.83	23.01 ± 4.76
CCK-8
Control (pg/mL)	3482.63 ± 154.25	3650.73 ± 55.08	3606.74 ± 129.42	3599.28 ± 120.15
Pigment gallstone (pg/mL)	3524.50 ± 79.29	3597.64 ± 86.55	3498.01 ± 107.14	3436.09 ± 82.96a

^aP < 0.05,

^bP < 0.01 vs the control group. VIP: Vasoactive intestinal peptide; CCK-8: Cholecystokinin octapeptide.