Death decoy receptor overexpression and increased malignancy risk in colorectal cancer

Table 1 Correlation of colorectal cancer clinicopathological variables with immunohistochemical staining patterns of human epidermal growth factor receptor 2 and death decoy receptor expression

Variable	n	HER2		P value1	DcR3		P value1
		Positive	Negative		Positive	Negative
Age
< 60	182	34	148	0.847	109	73	0.497
≥ 60	118	21	97		66	52
Sex
Male	171	30	141	0.684	102	69	0.595
Female	129	25	104		73	56
Tumor size (cm)
< 5	194	26	168	0.003	106	88	0.279
≥ 5	106	29	77		51	55
Differentiation grade
Well	73	11	62	0.385	29	44
Moderate	174	31	143		101	73	< 0.001
Poor	53	13	40		45	8
Lymph node status
Negative	161	32	129	0.457	74	87	< 0.001
Positive	139	23	116		101	38
Distant metastasis
M0	273	49	224	0.774	157	116	0.357
M1	27	6	21		18	9
Perineural invasion
Negative	285	51	231	0.9002	163	119	0.459
Positive	18	4	14		12	6
pTNM stage
I	50	4	46	0.0692	16	34	< 0.001
II	110	18	92		52	58
III	90	23	67		66	24
IV	50	10	40		41	9

¹Pearson’s χ² test;

²Adjusted χ² test. HER2: Human epidermal growth factor receptor 2; DcR3: Death decoy receptor; pTNM: The tumor, node, metastasis classification.