Medicinal plants against hepatitis C virus

doi:10.3748/wjg.v20.i11.2941

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Mar 21, 2014 (publication date) through Nov 29, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2014; 20(11): 2941-2947
Published online Mar 21, 2014. doi: 10.3748/wjg.v20.i11.2941

Table 1 Medicinal plant phytochemicals as anti- hepatitis C virus agents

Phytochemicals	Viral step	Effect
Diosgenin[43]	Replication	Inhibition of transcription factor 3 and signal transducer
Silymarin/silibinin[37,44,45]	Viral entry (viral attachment) Replication	Inhibition of core protein and NS5 RNA-dependent RNA polymerase
Iridoids[46,47]	Viral entry	Blockage of E2 and CD81 contact
Naringenin[48,49]	Viral assembly	Suppression of core protein activity
EGCG[50,51]	Viral entry	Disturbance in glycoprotein activity and Inhibition of cell-cell transmission
Quercetin[52,53]	Replication	Inhibition of IRES activity and NS3 polymerase
Ladanein[54]	Post attachment entry step	Inhibition of receptor interactions, virus endocytosis, or membrane fusion
Luteolin and apigenin[55]	Replication	Inhibition of NS5B polymerase activity

IRES: Internal ribosomal entry site. EGCG: Epigallocatechin gallate.

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Citation: Ashfaq UA, Idrees S. Medicinal plants against hepatitis C virus. World J Gastroenterol 2014; 20(11): 2941-2947
URL: https://www.wjgnet.com/1007-9327/full/v20/i11/2941.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i11.2941