Expression of P53 oncoprotein in benign and malignant lesions of large bowel

Table 1 P53 protein expression in colorectal cancer and other tissues of large bowel

Group	n	-	+	++	+++	Positive rate (%)
NMOLB	13	13	0	0	0	0
Non-neoplastic polyps	6	6	0	0	0	0
Paracancerous mucose	53	46	3	0	0	13.21
Adenomas	11	9	2	0	0	18.18
Carcinomas	76	44	8	16	8	42.11b

^bP < 0.01. NMOLB: Normal mucosae of large bowel.

Table 2 Correlation between P53 expression and tumor differentiation

Group	n	-	+	++	+++	Positive rate (%)
Well/moderately-differentiated	49	33	3	8	4	30.61
Poorly-differentiated	11	4	2	3	2	63.64a
Mucous	16	6	2	6	2	62.50a

^aP < 0.05, compared with well/moderately differentiated.

Table 3 Correlation between P53 expression and serosal invasion and lymph node metastasis

P53 expression	Serosal invasion		Lymph node metastasis
	-	+	-	+
-	21	23	37	5
+	3	5	5	3
++, +++	5	19a	16	8c

^aP < 0.05, P53(++, +++) vs P53(-) or P53(+);

^cP < 0.05, P53(+-+++) vs P53(-).