Overexpression and mutations of tumor suppressor gene p53 in hepatocellular carcinoma

Table 1 Correlations between p53 overexpression and clinicopathological features of Hepatocellular carcinoma

Clinicopathological features	Number of cases	p53 expression(+)	p53 expression(-)	Significance
Tumor size (cm)
< 3	3	1	2
3-5	5	2	3	a
> 5	30	13	17
Classification
Trabecular	15	5	10
Pseudoglandular	16	8	8	b
Compact	7	3	4
Grade
I	3	1	2
II	7	2	5	c
III	15	5	10
IV	13	8	5
Metastasis
Positive	14	10	4
Negative	24	6	8	d

a and b: Significant; c and d: P < 0.05.

Table 2 Correlations between p53 mutations and the clinicopathological features of Hepatocellular carcinoma

Clinicopathological features	Number ofcases	p53 expression (+)	p53 expression (-)	Significance
Tumor size (cm)
< 5	8	0	8
> 5	30	9	21
Classification
Trabecular	15	4	11
Pseudoglandular	16	3	13	b
Compact	7	2	7
Grade
I	3	0	3
II	7	1	6	c
III	15	2	13
IV	13	6	7
Metastasis
Positive	14	6	8
Negative	24	6	21	d

b: Not significant; a, c and d: P < 0.05.